Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522607 | 0.88 | KDM4E (0.46) | TP53MAPTCYP2C9KDM4EHPGD | |
| SCHEMBL6527550 | 0.83 | HCAR3 (0.38) | ICMTPLA2G4BGMNNTP53POLB | |
| SCHEMBL6521346 | 0.83 | ALOX12 (0.47) | POLBKDM4EALDH1A1 | |
| SCHEMBL6518242 | 0.81 | ICMT (0.38) | ICMTGPR84PLA2G4BGMNNTP53 | |
| SCHEMBL6520453 | 0.77 | GMNN (0.40) | ICMTGPR84PLA2G4BGMNNTP53 | |
| SCHEMBL6521996 | 0.77 | KDM4E (0.41) | ICMTPLA2G4BGMNNTP53POLB | |
| SCHEMBL12793317 | 0.76 | ITGB1 (0.48) | POLBITGB1ITGA4 | |
| SCHEMBL6521511 | 0.76 | GMNN (0.39) | ICMTPLA2G4BGMNNTP53POLB | |
| SCHEMBL3429743 | 0.76 | FAAH (0.39) | ICMTGPR84PLA2G4BGMNNTP53 | |
| SCHEMBL6524114 | 0.75 | RAB9A (0.41) | ICMTTP53MAPTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | SIGNUM BIOSCIENCES, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | SIGNUM BIOSCIENCES, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | SIGNUM BIOSCIENCES, INC. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | MPO, CYSLTR1, HNMT | ICMT 326/4885GPR84 120/4885PLA2G4B 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.