SCHEMBL6537301

SCHEMBL6537301

CCCc1ccc(C=Cc2ccc(C(=O)Cl)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 8/20 0.53
PLK1 P53350 1/20 0.50
ALDH1A1 P00352 3/20 0.49
POLB P06746 3/20 0.49
CTDSP1 Q9GZU7 3/20 0.49
KDM4E B2RXH2 2/20 0.49
GAA P10253 1/20 0.49
KMT2A Q03164 3/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
MAPT P10636 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ESR1 P03372 1/20 0.43
ESR2 Q92731 1/20 0.43
MITF O75030 1/20 0.43
HPGD P15428 1/20 0.43
KLF5 Q13887 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
THRA P10827 6/20 0.42
CNR2 P34972 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537300 1.00 THRB (0.53) THRBPLK1ALDH1A1POLBCTDSP1
SCHEMBL1019681 0.89 PLK1 (0.60) THRBPLK1ALDH1A1POLBCTDSP1
SCHEMBL7316586 0.84 RARB (0.56) THRBPLK1ALDH1A1POLBCTDSP1
SCHEMBL8103655 0.82 RARB (0.59) THRBPLK1ALDH1A1POLBCTDSP1
SCHEMBL994963 0.81 HDAC1 (0.48) ALDH1A1MAPTHPGD
SCHEMBL9679271 0.81 HDAC1 (0.48) ALDH1A1MAPTHPGD
SCHEMBL994964 0.81 HDAC1 (0.48) ALDH1A1MAPTHPGD
SCHEMBL11768170 0.81 ALDH1A1 (0.50) THRBPLK1ALDH1A1POLBCTDSP1
SCHEMBL11768167 0.81 ALDH1A1 (0.50) THRBPLK1ALDH1A1POLBCTDSP1
SCHEMBL14029964 0.80 THRB (0.54) THRBPLK1ALDH1A1POLBCTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040233377-A1 Liquid crystal display device COGNOA, INC. 2004-11-25 US disclosed
US-6757044-B2 Liquid crystal display device with spacers controlling thickness of liquid crystal layer HITACHI, LTD. (JP) 2004-06-29 US disclosed
US-20030002005-A1 Liquid crystal display device with spacers controlling thickness of liquid crystal layer IPS ALPHA SUPPORT CO., LTD. (JP) 2003-01-02 US disclosed
US-6441880-B1 Normally closed liquid crystal display device using spacers coated with material having liquid crystal aligning ability by irradiation with polarized light HITACHI, LTD. (JP) 2002-08-27 US disclosed