SCHEMBL6544714

SCHEMBL6544714

CC(C)C(=O)c1cn(Cc2c(F)cccc2F)c2sc(-c3ccc(NC(=O)CC(C)(C)O)cc3)c(CN(C)Cc3ccccc3)c2c1=O

nearest known ligand 0.85

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 20/20 0.85
MEN1 O00255 1/20 0.70
KMT2A Q03164 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7826642 0.99 GNRHR (0.84) GNRHRMEN1KMT2A
SCHEMBL6545383 0.92 GNRHR (1.00) GNRHRMEN1KMT2A
SCHEMBL7006717 0.92 GNRHR (0.89) GNRHRMEN1KMT2A
SCHEMBL7828327 0.92 GNRHR (1.00) GNRHRMEN1KMT2A
Hydrochloric Acid SCHEMBL7827346 0.91 GNRHR (0.99) GNRHRMEN1KMT2A
Hydrochloric Acid SCHEMBL7498171 0.91 GNRHR (0.88) GNRHRMEN1KMT2A
Hydrochloric Acid SCHEMBL7826617 0.91 GNRHR (0.99) GNRHRMEN1KMT2A
SCHEMBL7006144 0.90 GNRHR (1.00) GNRHRMEN1KMT2A
Hydrochloric Acid SCHEMBL7497376 0.90 GNRHR (0.99) GNRHRMEN1KMT2A
SCHEMBL7833581 0.89 GNRHR (0.89) GNRHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040116522-A1 Medicinal solutions TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-06-17 US disclosed
EP-1393747-A1 PREVENTIVES/REMEDIES FOR ALZHEIMER'S DISEASE Takeda Chemical Industries, Ltd. (JP) 2004-03-03 EP disclosed
US-20040034039-A1 Solid preparations TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-19 US disclosed
US-20040023987-A1 Sustained release compositions TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-05 US disclosed
EP-1374855-A1 MEDICINAL SOLUTIONS Takeda Chemical Industries, Ltd. (JP) 2004-01-02 EP disclosed
US-20030134863-A1 Preventives/remedies for alzheimer's disease TAKEDA CHEMICAL INDUSTRIES LTD. (JP) 2003-07-17 US disclosed
EP-1319409-A1 SOLID PREPARATIONS Takeda Chemical Industries, Ltd. (JP) 2003-06-18 EP disclosed
EP-1291023-A1 SUSTAINED RELEASE COMPOSITIONS Takeda Chemical Industries, Ltd. (JP) 2003-03-12 EP disclosed
US-6329388-B2 GONADOTROPIN-RELEASING HORMONE ANTAGONIZING ACTIVITY; USEFUL FOR PREVENTING OR TREATING SEX HORMONE-DEPENDENT DISEASES, E.G., SEX HORMONE-DEPENDENT CANCERS (E.G., PROSTATIC CANCER, UTERINE CANCER, BREAST CANCER, PITUITARY TUMOR) TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-12-11 US disclosed
US-6297255-B1 GONADOTROPIN-RELEASING HORMONE ANTAGONIZING ACTIVITY; PREVENTING OR TREATING SEX HORMONE-DEPENDENT DISEASES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-10-02 US disclosed
US-6262267-B1 HAS GONADOTROPIN-RELEASING HORMONE ANTAGONIZING ACTIVITY; USEFUL FOR PREVENTING OR TREATING SEX HORMONE-DEPENDENT DISEASES, E,G., SEX HORMONE-DEPENDENT CANCERS E.G., PROSTATIC CANCER, UTERINE CANCER, BREAST CANCER, PITUITARY TUMOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-07-17 US disclosed
US-20010001104-A1 Thienopyridine compounds, their production and use FURUYA SHUICHI (JP) 2001-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030134863-A1 Preventives/remedies for alzheimer's disease ACHE, GNRHR, PSEN1 GNRHR 2/4885MEN1 477/4885KMT2A 1190/4885
US-20040023987-A1 Sustained release compositions NGLY1, GHSR, GHRHR GNRHR 46/4885MEN1 710/4885KMT2A 4627/4885
US-20010001104-A1 Thienopyridine compounds, their production and use PRLHR, PGR, GNRHR GNRHR 3/4885MEN1 517/4885KMT2A 446/4885
US-20040034039-A1 Solid preparations GYS1, GYS2, SI GNRHR 3501/4885MEN1 3398/4885KMT2A 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.