Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181563 | 0.86 | CFTR (0.48) | MAPTNPC1RAB9AKMT2ATP53 | |
| SCHEMBL30074263 | 0.86 | CFTR (0.48) | MAPTNPC1RAB9AKMT2ATP53 | |
| SCHEMBL6550908 | 0.80 | CFTR (0.41) | MAPTNPC1KMT2AOPRM1TP53 | |
| SCHEMBL6552460 | 0.80 | ESR1 (0.51) | MAPTKMT2ASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL28606394 | 0.80 | MDM2 (0.40) | MAPTKMT2AOPRM1PGRTP53 | |
| Propionic Acid SCHEMBL4796324 | 0.78 | PKM (0.41) | MAPTRAB9AKMT2AOPRM1TP53 | |
| SCHEMBL28609498 | 0.76 | PGR (0.38) | MAPTKMT2APGRTP53SMN1; SMN2 | |
| SCHEMBL14462993 | 0.73 | S100A4 (0.42) | KMT2ASMN1; SMN2MEN1ALDH1A1TDP1 | |
| SCHEMBL28610336 | 0.73 | NPSR1 (0.57) | MAPTKMT2AOPRM1OPRL1PGR | |
| SCHEMBL20414407 | 0.73 | KMT2A (0.53) | MAPTNPC1RAB9AKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047411-B1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | HARVARD COLLEGE (US) | 2004-02-11 | — | — | EP | disclosed |