Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074263 | 0.90 | CFTR (0.48) | CFTRGOPCHSP90AA1KDM4EGAA | |
| SCHEMBL181563 | 0.90 | CFTR (0.48) | CFTRGOPCHSP90AA1KDM4EGAA | |
| SCHEMBL6552460 | 0.84 | ESR1 (0.51) | CFTRGOPCMDM2HSP90AA1KDM4E | |
| SCHEMBL6550929 | 0.80 | MAPT (0.46) | CFTRGOPCOPRM1MEN1KMT2A | |
| SCHEMBL28606394 | 0.80 | MDM2 (0.40) | CFTRGOPCOPRM1MDM2MEN1 | |
| SCHEMBL28609498 | 0.80 | PGR (0.38) | CFTRGOPCMDM2MEN1KMT2A | |
| Propionic Acid SCHEMBL4796324 | 0.78 | PKM (0.41) | CFTRGOPCOPRM1KDM4EGAA | |
| SCHEMBL14462993 | 0.77 | S100A4 (0.42) | CFTRGOPCHSP90AA1MEN1KMT2A | |
| SCHEMBL28610336 | 0.73 | NPSR1 (0.57) | CFTRGOPCOPRM1GAAMEN1 | |
| SCHEMBL28357232 | 0.72 | MAPT (0.44) | CFTRGOPCKDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047411-B1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | HARVARD COLLEGE (US) | 2004-02-11 | — | — | EP | disclosed |