Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181563 | 0.87 | CFTR (0.48) | PKMKMT2ALMNACFTRGOPC | |
| SCHEMBL30074263 | 0.87 | CFTR (0.48) | PKMKMT2ALMNACFTRGOPC | |
| SCHEMBL6552460 | 0.81 | ESR1 (0.51) | PKMKMT2ALMNACFTRGOPC | |
| SCHEMBL6550908 | 0.78 | CFTR (0.41) | PKMKMT2ALMNACFTRGOPC | |
| SCHEMBL6550929 | 0.78 | MAPT (0.46) | KMT2ACFTRGOPCSMN1; SMN2OPRM1 | |
| SCHEMBL28606394 | 0.78 | MDM2 (0.40) | KMT2ALMNACFTRGOPCSMN1; SMN2 | |
| SCHEMBL28609498 | 0.74 | PGR (0.38) | KMT2ALMNACFTRGOPCSMN1; SMN2 | |
| SCHEMBL14462993 | 0.74 | S100A4 (0.42) | KMT2ACFTRGOPCSMN1; SMN2THRB | |
| SCHEMBL28610336 | 0.74 | NPSR1 (0.57) | KMT2ALMNACFTRGOPCSMN1; SMN2 | |
| SCHEMBL7813324 | 0.74 | PKM (0.49) | PKMKMT2ACFTRGOPCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342038-B2 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | PRESIDENT AND FELLOW OF HARVARD COLLEGE (US) | 2008-03-11 | — | — | US | disclosed |
| US-20040242563-A1 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | CHILDREN'S MEDICAL CENTER CORPORATION | 2004-12-02 | — | — | US | disclosed |
| US-6800658-B2 | A POTENT AND SAFE INHIBITORS OF MAMMALIAN CELL PROLIFERATION FOR TREATING OR PREVENTING CANCER, BLOOD VESSEL PROLIFERATIVE DISORDERS, FIBROTIC DISORDERS AND ARTERIOSCLEROTIC CONDITIONS | CHILDREN'S MEDICAL CENTER CORPORATION | 2004-10-05 | — | — | US | disclosed |
| EP-1047411-B1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | HARVARD COLLEGE (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020198188-A1 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation | CHILDREN'S MEDICAL CENTER CORPORATION | 2002-12-26 | — | — | US | disclosed |
| US-20020128256-A1 | Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation | BRUGNARA CARLO (US) | 2002-09-12 | — | — | US | disclosed |
| EP-1047411-A4 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | HARVARD COLLEGE (US) | 2000-12-06 | — | — | EP | disclosed |
| EP-1047411-A1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-11-02 | — | — | EP | disclosed |
| EP-1032385-A1 | USE OF SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELLPROLIFERATION, DIARRHE AND SCOURS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999026624-A1 | USE OF SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION, DIARRHE AND SCOURS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 1999-06-03 | — | — | WO | disclosed |
| WO-1999026611-A1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128256-A1 | Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation | KCNN3, KCNN2, KCNN1 | PKM 672/4885KMT2A 2593/4885LMNA 1063/4885 |
| US-20040242563-A1 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | IDO1, ING2, MKI67 | PKM 992/4885KMT2A 1721/4885LMNA 2365/4885 |
| US-20020198188-A1 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation | IDO1, IDO2, ING2 | PKM 1126/4885KMT2A 1798/4885LMNA 2296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.