Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.61 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | RARB | P10826 | 1/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.61 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4651605 | 1.00 | PTGS2 (0.65) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL59197 | 0.92 | PTGS2 (0.74) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL480331 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL598280 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL2852282 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL121108 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL1590331 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL2818028 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| SCHEMBL917093 | 0.85 | PTGS2 (0.87) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 | |
| Hydrochloric Acid SCHEMBL5846545 | 0.84 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3CYP2C9AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893094-B2 | Amphiphilic pyridinium compounds, method of making and use thereof | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893094-B2 | Amphiphilic pyridinium compounds, method of making and use thereof | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20070105916-A1 | Amphiphilic pyridinium compounds, method of making and use thereof | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. | 2007-05-10 | — | — | US | disclosed |
| US-20070105916-A1 | Amphiphilic pyridinium compounds, method of making and use thereof | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. | 2007-05-10 | — | — | US | disclosed |
| EP-1385824-A2 | COMPOUNDS CO-INDUCING CHOLINERGIC UP-REGULATION AND INFLAMMATION DOWN-REGULATION AND USES THEREOF | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2004-02-04 | — | — | EP | disclosed |
| US-20020160988-A1 | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH | 2002-10-31 | — | — | US | disclosed |
| WO-2002065977-A2 | COMPOUNDS CO-INDUCING CHOLINERGIC UP-REGULATION AND INFLAMMATION DOWN-REGULATION AND USES THEREOF | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105916-A1 | Amphiphilic pyridinium compounds, method of making and use thereof | CXCL8, IL18, CCR8 | PTGS2 544/4885PTGS1 421/4885AKR1C3 586/4885 |
| US-20020160988-A1 | Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof | CHAT, ACHE, CHRNB2 | PTGS2 65/4885PTGS1 63/4885AKR1C3 822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.