Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Itaconate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.30 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itaconate SCHEMBL6552618 | 0.97 | ALOX15 (0.46) | ALOX15HSD17B10LDHASRRCA4 | |
| Itaconate SCHEMBL107588 | 0.90 | ALOX15 (0.41) | ALOX15HSD17B10LDHASRRTET2 | |
| Itaconate SCHEMBL5874668 | 0.86 | ALOX15 (0.39) | ALOX15HSD17B10LDHASRR | |
| Tetrapropylammonium SCHEMBL105588 | 0.81 | SLC22A1 (0.39) | ALOX15HSD17B10 | |
| Itaconate SCHEMBL3786177 | 0.79 | LMNA (0.43) | ALOX15HSD17B10LMNA | |
| Itaconate SCHEMBL107045 | 0.79 | CA4 (0.53) | CA4FAHD1 | |
| Itaconate SCHEMBL11694994 | 0.78 | CA4 (0.45) | ALOX15HSD17B10CA4 | |
| Itaconate SCHEMBL16880251 | 0.78 | EGLN1 (0.41) | ALOX15HSD17B10CA4LMNAALKBH5 | |
| Itaconate SCHEMBL106714 | 0.77 | CA4 (0.50) | CA4FAHD1 | |
| Itaconate SCHEMBL7511457 | 0.77 | CA4 (0.50) | CA4FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310792-B1 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | DOW SILICONES CORP (US) | 2021-07-21 | — | — | EP | disclosed |
| EP-3310793-B1 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | DOW SILICONES CORP (US) | 2021-06-09 | — | — | EP | disclosed |
| CN-107743493-B | Process for preparing acryloxysilanes | 美国陶氏有机硅公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-107743492-B | Process for preparing acryloxysilanes | 美国陶氏有机硅公司 | 2020-07-17 | — | — | CN | disclosed |
| US-10273254-B2 | Process for preparing an acryloyloxysilane | DOW CORNING CORPORATION (US) | 2019-04-30 | — | — | US | disclosed |
| US-10246473-B2 | Process for preparing an acryloyloxysilane | DOW CORNING CORPORATION (US) | 2019-04-02 | — | — | US | disclosed |
| EP-2785726-B1 | ESTER-FUNCTIONAL SILANES AND THE PREPARATION AND USE THEREOF; AND USE OF IMINIUM COMPOUNDS AS PHASE TRANSFER CATALYSTS | DOW SILICONES CORP (US) | 2018-08-01 | — | — | EP | disclosed |
| US-20180155371-A1 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | DOW SILICONES CORPORATION | 2018-06-07 | — | — | US | disclosed |
| US-20180134734-A1 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | DOW SILICONES CORPORATION | 2018-05-17 | — | — | US | disclosed |
| EP-3310793-A1 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | Dow Corning Corporation (US) | 2018-04-25 | — | — | EP | disclosed |
| EP-2621936-B1 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | DOW CORNING (US) | 2014-10-22 | — | — | EP | disclosed |
| EP-2785726-A2 | ESTER-FUNCTIONAL SILANES AND THE PREPARATION AND USE THEREOF; AND USE OF IMINIUM COMPOUNDS AS PHASE TRANSFER CATALYSTS | Dow Corning Corporation (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-2762482-A1 | Process for purifying an acryloyloxysilane | Dow Corning Corporation (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2621936-A2 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | Dow Corning Corporation (US) | 2013-08-07 | — | — | EP | disclosed |
| US-20130184482-A1 | Process For Preparing An Acryloyloxysilane | DOW CORNING CORPORATION (US) | 2013-07-18 | — | — | US | disclosed |
| WO-2013081820-A2 | ESTER-FUNCTIONAL SILANES AND THE PREPARATION AND USE THEREOF;AND USE OF IMINIUM COMPOUNDS AS PHASE TRANSFER CATALYSTS | DOW CORNING CORPORATION (US) | 2013-06-06 | — | — | WO | disclosed |
| WO-2012050761-A2 | PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE | DOW CORNING CORPORATION (US) | 2012-04-19 | — | — | WO | disclosed |
| EP-1048457-B1 | Lithographic printing plate precursor | FUJI PHOTO FILM CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-6455224-B1 | SUPPORT WITH HYDROPHILIC SURFACE AND PHOTOSENSITIVE LAYER CONTAINING INFRARED ABSORBENT WHICH CHANGES FROM HYDROPHILIC TO HYDROPHOBIC BY HEAT AND HYDROPHILIC POLYMER HAVING FUNCTIONAL GROUP RENDERING LAYER WATER DEVELOPABLE | FUJI PHOTO FILM CO., LTD. (JP) | 2002-09-24 | — | — | US | disclosed |
| EP-1048457-A2 | Lithographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |