Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3627628 | 0.89 | GPR3 (0.34) | GPR3BCHEACHEHTR2A | |
| Hydrochloric Acid SCHEMBL3684750 | 0.81 | ADRA2C (0.32) | — | |
| Ethane SCHEMBL8163438 | 0.76 | GPR3 (0.44) | GPR3BCHEACHEHTR2APOLB | |
| Hydrochloric Acid SCHEMBL19056256 | 0.76 | ALDH1A1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL618216 | 0.76 | GPR3 (0.42) | GPR3BCHEACHEHTR2APOLB | |
| Hydrochloric Acid SCHEMBL5689271 | 0.75 | GPR3 (0.31) | GPR3HTR2A | |
| Hydrochloric Acid SCHEMBL7756255 | 0.74 | ALDH1A1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL8599251 | 0.74 | GPR3 (0.41) | GPR3BCHEACHEHTR2APOLB | |
| Hydrochloric Acid SCHEMBL8378993 | 0.74 | GPR3 (0.41) | GPR3BCHEACHEHTR2APOLB | |
| SCHEMBL8702175 | 0.72 | GPR3 (0.44) | GPR3BCHEACHEHTR2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077215-B1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of a-olefins, process for their preparation and use of said metallocenes for the polymerization of a-olefins | SOLVAY (BE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1270615-A1 | ETHYLENE-BASE COPOLYMERS, PROCESS FOR PRODUCING THE SAME AND LUBRICATING OIL COMPOSITIONS CONTAINING THE SAME | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-6355747-B1 | FOR POLYMERIZATION OF PROPYLENE TO PRODUCE ISOTACTIC POLYPROPYLENE | SOLVAY POLYOLEFINS EUROPE-BELGIUM (BE) | 2002-03-12 | — | — | US | disclosed |
| EP-1077215-A1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of a-olefins, process for their preparation and use of said metallocenes for the polymerization of a-olefins | SOLVAY POLYOLEFINS EUROPE - BELGIUM (Société Anonyme) (BE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0754698-A2 | An olefin polymerization catalyst and a process for preparing olefin polymer | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-22 | — | — | EP | disclosed |