Sugi Predict

Sugi Predict / Compounds / SCHEMBL655414

SCHEMBL655414

SCHEMBL655414

ClCc1nc(-c2ccccc2)no1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 2/20 0.68
▸ RAB9A P51151 8/20 0.64
▸ NPC1 O15118 6/20 0.64
▸ L3MBTL1 Q9Y468 4/20 0.64
▸ CYP1A2 P05177 1/20 0.64
▸ CYP2C19 P33261 1/20 0.64
▸ SMN1; SMN2 Q16637 4/20 0.60
▸ ALDH1A1 P00352 4/20 0.60
▸ MAPK1 P28482 4/20 0.60
▸ TDP1 Q9NUW8 4/20 0.60
▸ TSHR P16473 4/20 0.60
▸ MEN1 O00255 1/20 0.60
▸ KMT2A Q03164 1/20 0.60
▸ CYP2D6 P10635 1/20 0.58
▸ KCNH2 Q12809 1/20 0.58
▸ NR1H4 Q96RI1 1/20 0.57
▸ HTR1A P08908 1/20 0.55
▸ HRH3 Q9Y5N1 1/20 0.55
▸ S1PR1 P21453 1/20 0.54
▸ MAPT P10636 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12617891 0.96 NOTUM (0.64) NOTUMRAB9ANPC1L3MBTL1CYP1A2
SCHEMBL15504863 0.85 RAB9A (0.70) NOTUMRAB9ANPC1L3MBTL1CYP1A2
SCHEMBL507782 0.83 NOTUM (0.72) NOTUMRAB9ANPC1L3MBTL1CYP1A2
SCHEMBL4288756 0.83 S1PR1 (0.61) RAB9ANPC1SMN1; SMN2TSHRMEN1
SCHEMBL10937283 0.81 SIRT2 (0.71) NOTUMRAB9ANPC1L3MBTL1CYP1A2
SCHEMBL2107628 0.81 NPC1 (0.64) NOTUMRAB9ANPC1SMN1; SMN2S1PR1
SCHEMBL26009685 0.81 NOTUM (0.56) NOTUMRAB9ANPC1L3MBTL1CYP1A2
SCHEMBL10904042 0.81 SMN1; SMN2 (0.59) RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1
SCHEMBL201423 0.81 NOTUM (0.56) NOTUMRAB9ANPC1L3MBTL1CYP1A2
SCHEMBL25916014 0.81 NOTUM (0.51) NOTUMRAB9ANPC1L3MBTL1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 348 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110734391-B 2, 3-diketone indole compound and preparation method and application thereof 山东大学 2023-05-02 — — CN claimed
CN-115093377-B Haloalkyl-containing 1,2, 4-oxadiazole derivative and preparation method and application thereof 贵州大学 2023-04-07 — — CN claimed
CN-115093377-A Haloalkyl-containing 1,2, 4-oxadiazole derivative and preparation method and application thereof 贵州大学 2022-09-23 — — CN claimed
CN-110734391-A 2, 3-diketone indole compound and preparation method and application thereof 山东大学 2020-01-31 — — CN claimed
US-20240300932-A1 N-PHENYLIMINE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF GUIZHOU UNIVERSITY (CN) 2024-09-12 — — US disclosed
WO-2024174317-A1 N-PHENYLIMINE-CONTAINING DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF 贵州大学 2024-08-29 — — WO disclosed
US-11970470-B1 {5-chloro-2-(2-(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)ethyl)phenyl}(phenyl)methanones as larvicidal agents King Faisal University (SA) 2024-04-30 — — US disclosed
CN-111548319-B 1, 1-dicyanooxime ether compound and application thereof 沈阳化工大学 2024-03-08 — — CN disclosed
US-20230312542-A1 HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2023-10-05 — — US disclosed
CN-116731003-A N-phenylimine-containing derivative, and preparation method and application thereof 贵州大学 2023-09-12 — — CN disclosed
CN-114195772-B 1,2, 4-oxadiazole derivative containing 1,3, 4-thiadiazole unit, and preparation method and application thereof 贵州大学 2023-06-30 — — CN disclosed
CN-110734391-B 2, 3-diketone indole compound and preparation method and application thereof 山东大学 2023-05-02 — — CN disclosed
US-5276035-A Central nervous system disorders; Parkinson's disease; antidepressant and dopaminergic agent NOVO NORDISK A/S (DK) 1994-01-04 — — US disclosed
EP-0541617-A1 1,4-DISUBSTITUTED PIPERAZINES. NOVO NORDISK AS (DK) 1993-05-19 — — EP disclosed
US-5112823-A Pesticides, miticides, insecticides, nematocides, molluscicides BASF AKTIENGESELLSCHAFT (DE) 1992-05-12 — — US disclosed
WO-1992001679-A1 1,4-DISUBSTITUTED PIPERAZINES NOVO NORDISK A/S (DK) 1992-02-06 — — WO disclosed
EP-0395985-A2 3(2H)-pyridazinone derivatives, their preparation method and their use for combating pests BASF Aktiengesellschaft (DE) 1990-11-07 — — EP disclosed
US-4497804-A Insecticidal, acaricidal, and nematicidal O-ethyl S-alkyl S-(1,2,4-oxadiazol-5-yl-methyl) phosphorodithiolate derivatives, compositions, and methods of use NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1985-02-05 — — US disclosed
EP-0081151-A1 Organophosphates, process for preparing them and pesticides containing them NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1983-06-15 — — EP disclosed
US-4067988-A 3-Phenyl-1,2,4-oxadiazole derivatives as antiinflammatory-antitussive agents LABORATOIRES CASSENNE (FR) 1978-01-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240300932-A1 N-PHENYLIMINE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF PNMT, NNMT, PAH NOTUM 443/4885RAB9A 4798/4885NPC1 1387/4885
US-11970470-B1 {5-chloro-2-(2-(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)ethyl)phenyl}(phenyl)methanones as larvicidal agents CASP3, CASP2, CASP7 NOTUM 1319/4885RAB9A 3675/4885NPC1 1200/4885
US-20230312542-A1 HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF VHL, MDM2, NEDD4 NOTUM 4584/4885RAB9A 1518/4885NPC1 2549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.