SCHEMBL6555686

SCHEMBL6555686

COc1ccc(C2=C(CC(=O)O)C(=O)c3ccccc32)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.59
SRC P12931 2/20 0.59
FGFR2 P21802 2/20 0.59
FGFR4 P22455 2/20 0.59
FGFR3 P22607 2/20 0.59
PPARG P37231 1/20 0.58
HSP90AA1 P07900 7/20 0.54
MAPT P10636 5/20 0.54
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
KDM4E B2RXH2 3/20 0.54
ALDH1A1 P00352 3/20 0.54
NPC1 O15118 2/20 0.54
TP53 P04637 2/20 0.54
RAB9A P51151 2/20 0.54
LMNA P02545 2/20 0.54
HTT P42858 2/20 0.54
HKDC1 Q2TB90 2/20 0.54
NPSR1 Q6W5P4 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6555666 0.86 PPARG (0.76) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL6557827 0.81 PPARG (0.62) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL8196679 0.80 CDK4 (0.50) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL7099074 0.79 HSP90AA1 (0.53) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL4216332 0.75 MMP2 (0.62) SMN1; SMN2KDM4EALDH1A1HPGDMMP1
SCHEMBL144791 0.74 FGFR1 (1.00) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL14773924 0.73 ME2 (0.74) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL2236453 0.71 MAPT (0.73) MAPTMEN1KMT2ASMN1; SMN2KDM4E
SCHEMBL2489785 0.70 MAPT (1.00) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL13141855 0.70 BACE1 (0.62) FGFR1SRCFGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958288-B1 PHOTOCHROMIC NAPHTOPYRANE COLORANTS, METHOD FOR THE PRODUCTION AND USE THEREOF, PHOTOCHROMIC OBJECT RODENSTOCK GMBH (DE) 2004-03-03 EP disclosed
EP-0987260-B1 Photochromic spirofluorenopyrans RODENSTOCK GMBH (DE) 2004-03-03 EP disclosed
US-6331625-B1 EYEGLASS LENSES; RAPID COLOR AND BRIGHTNESS ADJUSTMENT OPTISCHE WERKE G. RODENSTOCK (DE) 2001-12-18 US disclosed
US-6225466-B1 FOR ARTICLES MADE OF SYNTHETIC RESIN MATERIALS; RAPID DARKENING AND BRIGHTENING RATES, DURABILITY OPTISCHE WERKE G. RODENSTOCK (DE) 2001-05-01 US disclosed
US-6146554-A FOR PHOTOCHROMIC PLASTIC LENSES IN MASS-DYEING PROCESSES OPTISCHE WERKE G. RODENSTOCK (DE) 2000-11-14 US disclosed
EP-0987260-A1 Photochromic spirofluorenopyrans Optische Werke G. Rodenstock (DE) 2000-03-22 EP disclosed
EP-0958288-A1 PHOTOCHROMIC NAPHTOPYRANE COLORANTS, METHOD FOR THE PRODUCTION AND USE THEREOF, PHOTOCHROMIC OBJECT Optische Werke G. Rodenstock (DE) 1999-11-24 EP disclosed
WO-1999015518-A1 PHOTOCHROMIC NAPHTOPYRANE COLORANTS, METHOD FOR THE PRODUCTION AND USE THEREOF, PHOTOCHROMIC OBJECT OPTISCHE WERKE G. RODENSTOCK (DE) 1999-04-01 WO disclosed