Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.48 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.45 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.45 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577982 | 0.86 | RORC (0.53) | RORCSMN1; SMN2ESRRAKDM4EMEN1 | |
| SCHEMBL15390942 | 0.84 | EPHX1 (0.47) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL29953794 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL974694 | 0.81 | PKM (0.51) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL10061909 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL4548035 | 0.80 | EPHX1 (0.70) | RORCSMN1; SMN2KDM4EMEN1MAPT | |
| SCHEMBL12511362 | 0.79 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL7055271 | 0.79 | MEN1 (0.50) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL10013751 | 0.79 | CA12 (0.48) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL9693477 | 0.78 | HTT (0.58) | SMN1; SMN2MEN1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2647622-B1 | KINESIN SPINDLE PROTEIN INHIBITORS AND APPLICATION THEREOF | FUJITSU LTD (JP) | 2017-04-19 | — | — | EP | disclosed |
| EP-1100483-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1100483-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | Abbott Laboratories (US) | 2001-05-23 | — | — | EP | disclosed |
| US-6166013-A | Glucocortiocoid-selective agents | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |
| WO-2000006137-A2 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0338310-B1 | REACTIVE DYES | BAYER AG (DE) | 1992-12-09 | — | — | EP | disclosed |
| EP-0338310-A1 | Reactive dyes | BAYER AG (DE) | 1989-10-25 | — | — | EP | disclosed |