Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093817 | 0.98 | ACHE (0.41) | BLMMAPTACHELMNAAPEX1 | |
| Hydrochloric Acid SCHEMBL7765956 | 0.95 | ACHE (0.39) | BLMMAPTACHELMNAAPEX1 | |
| Hydrochloric Acid SCHEMBL324011 | 0.86 | ACHE (0.52) | BLMMAPTACHELMNAAPEX1 | |
| Hydrochloric Acid SCHEMBL9497105 | 0.83 | APEX1 (0.48) | ACHELMNAAPEX1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2936558 | 0.82 | ACHE (0.52) | BLMMAPTACHELMNAAPEX1 | |
| Methacrylic Acid SCHEMBL6561454 | 0.81 | ACHE (0.52) | BLMMAPTACHEAPEX1CHRM5 | |
| Hydrochloric Acid SCHEMBL1703796 | 0.80 | ACHE (0.45) | ACHELMNAAPEX1ADRA2AADRA1A | |
| Hydrochloric Acid SCHEMBL8695365 | 0.80 | ACHE (0.45) | BLMMAPTACHEAPEX1ENPP2 | |
| Hydrochloric Acid SCHEMBL8222907 | 0.80 | ACHE (0.45) | BLMMAPTACHEAPEX1ENPP2 | |
| Hydrochloric Acid SCHEMBL424927 | 0.79 | CHRM5 (0.43) | BLMMAPTACHELMNAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925379-A | REMOVING BILE SALTS FROM PATIENT BY ADMINISTERING INTERPENETRATING POLYMER NETWORK COMPRISING CATIONIC POLYMER | GELTEX PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | claimed |
| US-11208425-B2 | Process for preparing polyol glycosides | SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) | 2021-12-28 | — | — | US | disclosed |
| US-20180170956-A1 | NOVEL PROCESS FOR PREPARING POLYOL GLYCOSIDES | SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) | 2018-06-21 | — | — | US | disclosed |
| US-20160052950-A1 | NOVEL PROCESS FOR PREPARING POLYOL GLYCOSIDES | SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) | 2016-02-25 | — | — | US | disclosed |
| EP-1014999-B1 | CATIONIC POLYMERS AS TOXIN-BINDING AGENTS | GENZYME CORP (US) | 2004-12-08 | — | — | EP | disclosed |
| US-6692732-B2 | Administering cationic polymers to mammals to prevent poisons or antigens from microorganisms such as bacteria, viruses, fungi or parasites; deactivation | GENZYME CORPORATION | 2004-02-17 | — | — | US | disclosed |
| US-20040009145-A1 | IONIC POLYMERS AS TOXIN-BINDING AGENTS | GELTEX PHARMACEUTICALS, INC. | 2004-01-15 | — | — | US | disclosed |
| US-6482402-B1 | BACTERICIDE AND CATIONIC POLYMER | GELTEX PHARMACEUTICALS, INC. | 2002-11-19 | — | — | US | disclosed |
| US-20020114774-A1 | Ionic polymers as toxin-binding agents | GELTEX PHARMACEUTICALS, INC. | 2002-08-22 | — | — | US | disclosed |
| US-6290947-B1 | IN ONE EMBODIMENT, THE POLYMER IS A COPOLYMER COMPRISING A MONOMER HAVING A PENDANT AMMONIUM GROUP AND A HYDROPHOBIC MONOMER. | GELTEX PHARMACEUTICALS, INC. | 2001-09-18 | — | — | US | disclosed |
| EP-1014999-A1 | CATIONIC POLYMERS AS TOXIN-BINDING AGENTS | GELTEX PHARMACEUTICALS, INC. (US) | 2000-07-05 | — | — | EP | disclosed |
| US-6007803-A | ADMINISTERING TO MAMMAL A CATIONIC POLYMER TO INHIBIT PATHOGENIC TOXINS | GELTEX PHARMACEUTICALS, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5925379-A | REMOVING BILE SALTS FROM PATIENT BY ADMINISTERING INTERPENETRATING POLYMER NETWORK COMPRISING CATIONIC POLYMER | GELTEX PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| WO-1999015186-A1 | CATIONIC POLYMERS AS TOXIN-BINDING AGENTS | GELTEX PHARMACEUTICALS, INC. (US) | 1999-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170956-A1 | NOVEL PROCESS FOR PREPARING POLYOL GLYCOSIDES | UGGT1, DOHH, P4HA1 | ACHE 3586/4885CHRM1 1350/4885CHRM3 3719/4885 |
| US-20020114774-A1 | Ionic polymers as toxin-binding agents | PIGS, ANTXR2, MSN | ACHE 1151/4885CHRM1 592/4885CHRM3 836/4885 |
| US-20160052950-A1 | NOVEL PROCESS FOR PREPARING POLYOL GLYCOSIDES | UGGT1, DOHH, P4HA1 | ACHE 3586/4885CHRM1 1350/4885CHRM3 3719/4885 |
| US-11208425-B2 | Process for preparing polyol glycosides | DOHH, DDOST, UGGT1 | ACHE 3571/4885CHRM1 1605/4885CHRM3 3837/4885 |
| US-20040009145-A1 | IONIC POLYMERS AS TOXIN-BINDING AGENTS | PIGS, ANTXR2, MSN | ACHE 1151/4885CHRM1 592/4885CHRM3 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.