Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | IAPP | P10997 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957184 | 0.86 | LTB4R (0.58) | LTB4R | |
| SCHEMBL6559825 | 0.82 | ALDH1A1 (0.49) | LTB4RCNR1CNR2CTSDLTB4R2 | |
| SCHEMBL8949549 | 0.82 | ABCB1 (0.49) | LTB4RCNR1CNR2CTSDPTPN1 | |
| SCHEMBL6561729 | 0.81 | L3MBTL1 (0.51) | LTB4R | |
| SCHEMBL6561407 | 0.81 | MTNR1A (0.40) | LTB4RCNR1CNR2IAPPPTPN1 | |
| SCHEMBL27324155 | 0.80 | IAPP (0.51) | IAPP | |
| SCHEMBL9312500 | 0.78 | LMNA (0.53) | LTB4RCNR1CNR2LTB4R2 | |
| SCHEMBL8586495 | 0.77 | LTB4R (0.57) | LTB4RCNR1CNR2LTB4R2 | |
| SCHEMBL31613792 | 0.75 | TP53 (0.55) | CNR1CNR2CTSD | |
| SCHEMBL1400620 | 0.75 | TP53 (0.55) | CNR1CNR2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904079-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2004-03-24 | — | — | EP | disclosed |
| EP-0904079-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0904079-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5859051-A | ACETYLPHENOL DERIVATIVES | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1997027857-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |