Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 5/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | S100A4 | P26447 | 2/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NAT1 | P18440 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2766272 | 0.98 | ACLY (0.46) | ACLYPTGDR2S100A4FBP1KMT2A | |
| SCHEMBL2742906 | 0.89 | S100A4 (0.42) | ACLYPTGDR2S100A4HSP90AA1CYP1A2 | |
| SCHEMBL8178017 | 0.86 | PTGDR2 (0.46) | ACLYPTGDR2S100A4FBP1KMT2A | |
| SCHEMBL196568 | 0.85 | S100A4 (0.48) | S100A4HSP90AA1 | |
| SCHEMBL760785 | 0.84 | ACLY (0.48) | ACLYPTGDR2S100A4FBP1KMT2A | |
| SCHEMBL3696775 | 0.83 | S100A4 (0.46) | S100A4HSP90AA1 | |
| SCHEMBL4301050 | 0.83 | S100A4 (0.46) | S100A4HSP90AA1 | |
| SCHEMBL3695968 | 0.83 | S100A4 (0.46) | S100A4HSP90AA1 | |
| SCHEMBL3699050 | 0.83 | S100A4 (0.46) | S100A4HSP90AA1 | |
| SCHEMBL8775893 | 0.80 | ALOX5 (0.57) | KMT2AMEN1KDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124797-B1 | N-ARYLSULFONYL AMINO ACID OMEGA AMIDES | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6335333-B1 | MATRIX METALLOPROTEINASE INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-01 | — | — | US | disclosed |
| EP-1124797-A1 | N-ARYLSULFONYL AMINO ACID OMEGA AMIDES | Aventis Pharma Deutschland GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-6201130-B1 | FOR THE THERAPY AND PROPHYLAXIS OF DISORDERS INVOLVING MATRIX-DEGRADING METALLOPROTEINASES; ANTIINFLAMMATORY AGENTS | AVENTIS PHARMA DUETSCHLAND GMBH (DE) | 2001-03-13 | — | — | US | disclosed |
| WO-2000027808-A1 | N-ARYLSULFONYL AMINO ACID OMEGA AMIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-05-18 | — | — | WO | disclosed |