Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 4/20 | 0.48 |
| ▸ | S100A4 | P26447 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196679 | 0.84 | TRPV4 (0.52) | S100A4TRPV4KDM4EALDH1A1HPGD | |
| SCHEMBL6562906 | 0.84 | ACLY (0.47) | ACLYS100A4PTGDR2FBP1KMT2A | |
| Hydrochloric Acid SCHEMBL2766272 | 0.82 | ACLY (0.46) | ACLYS100A4PTGDR2FBP1KMT2A | |
| SCHEMBL2894066 | 0.80 | PTPRC (0.43) | ACLYS100A4PTGDR2KMT2AKDM4E | |
| SCHEMBL3873206 | 0.80 | ACLY (0.39) | ACLYPTGS2PTGS1ALDH1A1HSD17B10 | |
| SCHEMBL313390 | 0.78 | ALDH1A1 (0.46) | FBP1PTGS2PTGS1ALDH1A1HSD17B10 | |
| SCHEMBL9840644 | 0.77 | KIF18A (0.51) | ACLYKMT2AMEN1KDM4ECYP1A2 | |
| SCHEMBL4202592 | 0.77 | PTGS2 (0.55) | S100A4FBP1KDM4ECYP1A2PTGS2 | |
| SCHEMBL15879481 | 0.76 | PTGS2 (0.48) | KMT2AMEN1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL6291041 | 0.76 | PTPN1 (0.50) | KMT2AMEN1KDM4ECYP1A2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841772-B1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI SA (FR) | 2015-05-06 | — | — | EP | disclosed |
| EP-1670766-B1 | Bicyclic imino acid derivatives for the treatment of (inter alia) diseases relating to the locomotor system | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-03-21 | — | — | EP | disclosed |
| US-8039481-B2 | Tetrahydrofuran derivatives for use as inhibitors of matrix metalloproteinases | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
| US-20100279986-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-04 | — | — | US | disclosed |
| US-7803793-B2 | Heterocyclic derived metalloprotease inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20100105894-A1 | Cyclopropane compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. | 2010-04-29 | — | — | US | disclosed |
| EP-1694410-B1 | CYCLOPROPANE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2010-04-14 | — | — | EP | disclosed |
| EP-2089365-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2009-08-19 | — | — | EP | disclosed |
| US-20080306258-A1 | Cyclopropane compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. | 2008-12-11 | — | — | US | disclosed |
| US-20080261994-A1 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. | 2008-10-23 | — | — | US | disclosed |
| WO-2005030728-A1 | BICYCLIC IMINO ACID DERIVATIVES USED AS INHIBITORS OF MATRIX-METALLOPROTEINASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | WO | disclosed |
| US-20030087945-A1 | Sulfonylaminocarboxylic acids | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-05-08 | — | — | US | disclosed |
| EP-0877018-B1 | Sulfonylaminocarboxylic acids | AVENTIS PHARMA GMBH (DE) | 2003-05-02 | — | — | EP | disclosed |
| US-6451824-B1 | Sulfonylaminocarboxylic acids | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-09-17 | — | — | US | disclosed |
| US-6355673-B1 | BONE DISORDERS; ANTIINFLAMMATORY AGENTS; WOUND HEALING AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-03-12 | — | — | US | disclosed |
| EP-0877019-B1 | Substituted diaminocarboxylic acid | HOECHST AG (DE) | 2001-12-12 | — | — | EP | disclosed |
| US-6159995-A | Substituted diaminocarboxylic acids | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| EP-0967201-A1 | Pharmaceutical agents containing sulfonamids as matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-12-29 | — | — | EP | disclosed |
| EP-0877019-A1 | Substituted diaminocarboxylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-11 | — | — | EP | disclosed |
| EP-0877018-A1 | Sulfonylaminocarboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087945-A1 | Sulfonylaminocarboxylic acids | MMP1, SERPINB1, MMP3 | ACLY 1461/4885S100A4 1080/4885PTGDR2 393/4885 |
| US-20080261994-A1 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | MMP13, MMP9, MMP11 | ACLY 672/4885S100A4 1351/4885PTGDR2 149/4885 |
| US-20100279986-A1 | HETEROCYCLIC DERIVED METALLOPROTEASE INHIBITORS | ADAM17, MMP25, ADAM33 | ACLY 1564/4885S100A4 2556/4885PTGDR2 340/4885 |
| US-20100105894-A1 | Cyclopropane compounds and pharmaceutical use thereof | MMP13, MMP9, MMP11 | ACLY 672/4885S100A4 1351/4885PTGDR2 149/4885 |
| US-20080306258-A1 | Cyclopropane compounds and pharmaceutical use thereof | MMP13, MMP9, MMP11 | ACLY 673/4885S100A4 1351/4885PTGDR2 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.