Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 8/20 | 0.46 |
| ▸ | METAP1 | P53582 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.39 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489352 | 0.78 | SMN1; SMN2 (0.61) | METAP2METAP1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL6561605 | 0.72 | METAP2 (0.64) | METAP2METAP1TSHRALDH1A1PYGL | |
| SCHEMBL6934858 | 0.69 | METAP2 (0.46) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6564599 | 0.69 | METAP2 (0.64) | METAP2METAP1NPC1RAB9A | |
| SCHEMBL6563124 | 0.68 | METAP2 (0.50) | METAP2METAP1NPC1RAB9AKMT2A | |
| SCHEMBL7360094 | 0.67 | METAP2 (0.60) | METAP2METAP1CYP2D6PYGL | |
| SCHEMBL6940184 | 0.67 | METAP2 (0.49) | METAP2METAP1NPC1RAB9A | |
| SCHEMBL7075351 | 0.66 | METAP2 (0.48) | METAP2METAP1MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL7358163 | 0.66 | METAP2 (0.67) | METAP2METAP1MAPK1NPC1RAB9A | |
| SCHEMBL6564663 | 0.65 | METAP2 (0.50) | METAP2METAP1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | claimed |