Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 4/20 | 0.40 |
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669552 | 0.91 | HPN (0.45) | KMT2AMEN1MAPTPRSS1HPN | |
| SCHEMBL6563625 | 0.84 | PRSS1 (0.43) | TMPRSS6HPGDLMNAPRSS1MRGPRX1 | |
| SCHEMBL6561827 | 0.81 | MRGPRX1 (0.51) | TMPRSS6PRSS1MRGPRX1F2PRSS2 | |
| SCHEMBL6565487 | 0.81 | MAPT (0.44) | HPGDKDM4ELMNAMAPK1MAPT | |
| SCHEMBL6563461 | 0.79 | PRSS1 (0.49) | TMPRSS6PRSS1MRGPRX1HPNPLAU | |
| SCHEMBL6561886 | 0.79 | PLAU (0.53) | KMT2AKDM4EMRGPRX1PLAUF2 | |
| SCHEMBL6565256 | 0.79 | AKR1C3 (0.44) | PRSS1MRGPRX1PLAUF2PRSS2 | |
| SCHEMBL7675063 | 0.77 | F2 (0.48) | TMPRSS6PRSS1PLAUF2PRSS2 | |
| SCHEMBL7670899 | 0.77 | PRSS1 (0.43) | TMPRSS6LMNAPRSS1HPNPLAU | |
| SCHEMBL6561878 | 0.77 | PRSS1 (0.43) | TMPRSS6PRSS1F2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |