Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | EIF4E | P06730 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565718 | 0.80 | ALDH1A1 (0.51) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL2781370 | 0.79 | KDM4E (0.85) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6567198 | 0.79 | LOXL2 (0.48) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL12245713 | 0.78 | SMN1; SMN2 (0.60) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8050280 | 0.78 | HSD17B1 (0.87) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11215130 | 0.77 | SREBF2 (0.82) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11213828 | 0.77 | SREBF2 (0.82) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11212983 | 0.77 | SREBF2 (0.82) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL4281217 | 0.77 | RAB9A (0.75) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6330424 | 0.77 | SREBF2 (0.70) | KDM4EKMT2ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |