Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570097 | 0.86 | SIGMAR1 (0.43) | SIGMAR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6569755 | 0.85 | TP53 (0.40) | KMT2AMEN1MITFLMNASMN1; SMN2 | |
| SCHEMBL6570156 | 0.68 | SIGMAR1 (0.43) | SIGMAR1SMN1; SMN2NPC1RAB9AHRH3 | |
| SCHEMBL18848916 | 0.64 | SIGMAR1 (0.48) | SIGMAR1 | |
| SCHEMBL12157071 | 0.62 | ADRB2 (0.48) | KMT2AMEN1MITFLMNASMN1; SMN2 | |
| SCHEMBL17084112 | 0.62 | ADRB2 (0.48) | KMT2AMEN1MITFLMNASMN1; SMN2 | |
| SCHEMBL25447405 | 0.61 | ADRB2 (0.46) | KMT2AMEN1LMNASMN1; SMN2RAB9A | |
| SCHEMBL156202 | 0.60 | HRH3 (0.76) | SIGMAR1KMT2AMEN1MITFRAB9A | |
| SCHEMBL12120376 | 0.60 | FPR2 (0.48) | SIGMAR1HRH3 | |
| SCHEMBL156934 | 0.60 | USP2 (0.58) | SIGMAR1KMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |