Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL141506 | 0.88 | ALDH1A1 (0.65) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| SCHEMBL30626639 | 0.88 | ALDH1A1 (0.65) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| Monoethanolamine SCHEMBL11317594 | 0.85 | ALDH1A1 (0.52) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| SCHEMBL6833268 | 0.84 | ALDH1A1 (0.60) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| Orthocresol SCHEMBL1232540 | 0.76 | TRPA1 (0.46) | ALDH1A1TSHRTDP1LMNAMEN1 | |
| SCHEMBL3157499 | 0.75 | ALDH1A1 (0.60) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| SCHEMBL2879775 | 0.74 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1LMNAMEN1 | |
| SCHEMBL2825479 | 0.74 | ALDH1A1 (0.78) | ALDH1A1TSHRTDP1LMNAMEN1 | |
| Tromethamine SCHEMBL2781894 | 0.73 | GABRA1 (0.48) | TSHRLMNAMEN1KMT2ACA2 | |
| Pyrogallol SCHEMBL3962362 | 0.73 | LMNA (0.57) | ALDH1A1TSHRTDP1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665111-A | Casting compound for electrical and electronic components and modules | SIEMENS AKTIENGESELLSCHAFT (DE) | 1987-05-12 | — | — | US | claimed |
| US-20240286321-A1 | ANISOTROPIC FILM AND METHOD FOR MANUFACTURING ANISOTROPIC FILM | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2024-08-29 | — | — | US | disclosed |
| EP-3728384-A1 | METHOD FOR PRODUCING ISOCYANATE MIXTURES CONTAINING ISOCYANURATE GROUPS | Covestro Deutschland AG (DE) | 2020-10-28 | — | — | EP | disclosed |
| CN-107001588-B | Curable epoxy resin composition | 陶氏环球技术有限责任公司 | 2020-09-01 | — | — | CN | disclosed |
| EP-1112297-B1 | METHOD FOR COATING A TEXTILE | COGNIS CORP (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-1208146-B1 | SCREEN COATING COMPOSITION AND METHOD FOR APPLYING SAME | COGNIS CORP (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1112307-B1 | SCREEN COATING COMPOSITION AND METHOD FOR APPLYING SAME | COGNIS CORP (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1208146-A4 | SCREEN COATING COMPOSITION AND METHOD FOR APPLYING SAME | COGNIS CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1208146-A1 | SCREEN COATING COMPOSITION AND METHOD FOR APPLYING SAME | Cognis Corporation (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0894097-A4 | RADIATION CURABLE RHEOLOGY MODIFIERS | HENKEL CORP (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2000011068-A1 | SCREEN COATING COMPOSITION AND METHOD FOR APPLYING SAME | COGNIS CORPORATION (US) | 2000-03-02 | — | — | WO | disclosed |
| US-5889076-A | Radiation curable rheology modifiers | HENKEL CORPORATION (US) | 1999-03-30 | — | — | US | disclosed |
| WO-1999010409-A1 | RADIATION-POLYMERIZABLE COMPOSITION AND PRINTING INKS CONTAINING SAME | HENKEL CORPORATION (US) | 1999-03-04 | — | — | WO | disclosed |
| EP-0894097-A1 | RADIATION CURABLE RHEOLOGY MODIFIERS | HENKEL CORPORATION (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1998044007-A1 | RADIATION-POLYMERIZABLE COMPOSITION AND PRINTING INKS CONTAINING SAME | HENKEL CORPORATION (US) | 1998-10-08 | — | — | WO | disclosed |
| US-5804671-A | Radiation curable rheology modifiers | HENKEL CORPORATION (US) | 1998-09-08 | — | — | US | disclosed |
| WO-1997038022-A1 | RADIATION CURABLE RHEOLOGY MODIFIERS | HENKEL CORPORATION (US) | 1997-10-16 | — | — | WO | disclosed |
| US-5484854-A | Modified phenolic resin, epoxy resin and curing agent molding material | KASHIMA OIL CO., LTD. (JP) | 1996-01-16 | — | — | US | disclosed |
| US-4665111-A | Casting compound for electrical and electronic components and modules | SIEMENS AKTIENGESELLSCHAFT (DE) | 1987-05-12 | — | — | US | disclosed |
| US-4004151-A | Detector for deep well logging | NOVAK WILLIAM P | 1977-01-18 | — | — | US | disclosed |