Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Pyrogallol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | MMP9 | P14780 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrogallol SCHEMBL28732500 | 0.76 | ALDH1A1 (0.75) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Orthocresol SCHEMBL1232540 | 0.76 | TRPA1 (0.46) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL170157 | 0.76 | ALDH1A1 (1.00) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL3532 | 0.76 | — | — | |
| Pyrogallol SCHEMBL3367606 | 0.74 | ALDH1A1 (0.71) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL27674772 | 0.73 | ALDH1A1 (0.80) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Tromethamine SCHEMBL218955 | 0.73 | CA12 (0.55) | LMNAALDH1A1CA2TDP1CA1 | |
| Tromethamine SCHEMBL6571798 | 0.73 | ALDH1A1 (0.52) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Pyrogallol SCHEMBL11661058 | 0.73 | ALDH1A1 (0.92) | LMNAALOX15ALDH1A1HPGDHSD17B10 | |
| Tromethamine SCHEMBL2953454 | 0.73 | LMNA (0.77) | LMNAMEN1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795077-B | Naphthol calixarene compound, process for producing the same, photosensitive composition, resist material, and coating film | DIC株式会社 | 2021-03-30 | — | — | CN | disclosed |
| US-7485407-B2 | Siloxane compound, photoresist composition including the siloxane compound and method of forming a pattern using the photoresist composition | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2009-02-03 | — | — | US | disclosed |
| US-20070148590-A1 | Siloxane compound, photoresist composition including the siloxane compound and method of forming a pattern using the photoresist composition | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2007-06-28 | — | — | US | disclosed |