Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581698 | 0.95 | ALDH1A1 (0.32) | TYMSALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL6291852 | 0.87 | CNR2 (0.35) | ALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL6291868 | 0.81 | KMT2A (0.36) | ALDH1A1SMN1; SMN2HTTPOLB | |
| SCHEMBL5776518 | 0.80 | OPRM1 (0.31) | ALDH1A1L3MBTL1OPRM1 | |
| SCHEMBL6585426 | 0.80 | HPGDS (0.33) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6582104 | 0.77 | IDO1 (0.34) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6152031 | 0.76 | OPRM1 (0.32) | OPRM1 | |
| SCHEMBL5776140 | 0.73 | GSK3A (0.33) | ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6288862 | 0.72 | ALPL (0.32) | — | |
| SCHEMBL5774080 | 0.71 | GRM2 (0.30) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406888-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | claimed |
| WO-2003004483-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | claimed |
| EP-1406888-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004483-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | disclosed |