Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797835 | 0.90 | OPRM1 (0.32) | OPRM1OPRD1OPRK1POLBALDH1A1 | |
| SCHEMBL6582379 | 0.75 | OPRM1 (0.32) | OPRM1OPRD1OPRK1 | |
| SCHEMBL6584102 | 0.71 | ALDH1A1 (0.44) | POLBALDH1A1KDM4EGAAMAPT | |
| SCHEMBL6582935 | 0.70 | MMP2 (0.36) | POLBALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL7416332 | 0.68 | PKLR (0.48) | POLBALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL7471562 | 0.65 | ESR1 (0.50) | KDM4E | |
| SCHEMBL14337887 | 0.65 | TDP1 (0.47) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL19926708 | 0.65 | ACHE (0.39) | OPRM1POLBALDH1A1KDM4ELMNA | |
| SCHEMBL6582614 | 0.65 | MAPT (0.37) | POLBCA12CA1CA2CA9 | |
| SCHEMBL10474724 | 0.64 | CA1 (0.43) | POLBCA1CA2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146044-B1 | CNS active cyclobuta-indole carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-09-01 | — | — | EP | disclosed |
| EP-1146044-A1 | CNS active cyclobuta-indole carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-10-17 | — | — | EP | disclosed |