Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28947738 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HPGDCYP3A4MAPK1MAPT | |
| SCHEMBL4708636 | 0.83 | MTNR1A (0.46) | CYP3A4MAPTPOLBL3MBTL1KDM4E | |
| SCHEMBL48106 | 0.83 | MTNR1A (0.59) | HSD17B10MTNR1AMTNR1B | |
| SCHEMBL5730634 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HPGDCYP3A4MAPK1MAPT | |
| SCHEMBL47914 | 0.80 | APLNR (0.50) | ALDH1A1POLBRAB9ANPC1HSD17B10 | |
| SCHEMBL7369145 | 0.80 | POLB (0.63) | ALDH1A1HPGDCYP3A4MAPK1MAPT | |
| SCHEMBL1350452 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HPGDCYP3A4MAPK1RAB9A | |
| SCHEMBL14864225 | 0.79 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP3A4MAPK1MAPT | |
| SCHEMBL27974256 | 0.79 | POLB (0.43) | ALDH1A1CYP3A4MAPTPOLBL3MBTL1 | |
| SCHEMBL27387802 | 0.78 | ALOX5 (0.52) | ALDH1A1HPGDCYP3A4MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| EP-1095939-B1 | Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds | PFIZER PROD INC (US) | 2004-01-07 | — | — | EP | disclosed |
| US-20030236268-A1 | Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds | CARON STEPHANIE (US) | 2003-12-25 | — | — | US | disclosed |
| US-6486325-B1 | Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds | PFIZER INC | 2002-11-26 | — | — | US | disclosed |
| EP-1095939-A2 | Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds | Pfizer Products Inc. (US) | 2001-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236268-A1 | Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP1B1, PAICS | ALDH1A1 284/4885HPGD 3196/4885CYP3A4 34/4885 |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | NOS3, NOS1, NOS2 | ALDH1A1 362/4885HPGD 763/4885CYP3A4 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.