Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589130 | 0.82 | CHRM3 (0.58) | CHRM3HTTKEAP1NFE2L2CHRM2 | |
| SCHEMBL6589596 | 0.80 | CHRM3 (0.42) | CHRM3HTTKEAP1NFE2L2CHRM2 | |
| SCHEMBL17871674 | 0.78 | ALDH1A1 (0.52) | CHRM3KEAP1NFE2L2CHRM2CHRM1 | |
| SCHEMBL6590742 | 0.77 | KEAP1 (0.43) | OPRL1CHRM3KEAP1NFE2L2CHRM2 | |
| Bromomethane SCHEMBL19839345 | 0.76 | ALDH1A1 (0.50) | CHRM3KEAP1NFE2L2CHRM2CHRM1 | |
| SCHEMBL6587439 | 0.76 | ALDH1A1 (0.64) | KCNH2HRH1HTR2BCHRM3HTT | |
| SCHEMBL6587556 | 0.76 | CHRM2 (0.66) | CHRM3CHRM2CHRM1 | |
| SCHEMBL6589288 | 0.74 | GPR119 (0.49) | MEN1GAAMAPTKMT2ARBP4 | |
| SCHEMBL4967978 | 0.74 | ALDH1A1 (0.46) | CHRM3KEAP1NFE2L2CHRM2CHRM1 | |
| SCHEMBL6587461 | 0.73 | CHRM2 (0.52) | CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823423-B1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-06-16 | — | — | EP | claimed |
| EP-0823423-B1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-06-16 | — | — | EP | disclosed |
| EP-0823423-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |