SCHEMBL6587577

SCHEMBL6587577

Cc1[nH]nc(-c2cccc(N(C(=O)c3ccc(Cl)cc3)c3ccc(Cl)cc3)c2)c1Br

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 6/20 0.39
MAP2K4 P45985 4/20 0.35
TTK P33981 1/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
ATM Q13315 1/20 0.34
CHEK2 O96017 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
MAPT P10636 2/20 0.34
MEN1 O00255 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
GAA P10253 1/20 0.34
CYP2D6 P10635 1/20 0.34
ALOX15 P16050 1/20 0.34
ALOX12 P18054 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7097264 0.80 ALDH1A1 (0.45) GPBAR1MAPTHTTKMT2ANPSR1
SCHEMBL6590232 0.73 CNR1 (0.59) MAPT
SCHEMBL4850458 0.69 ALDH1A1 (0.41) GPBAR1NPC1MAPTHTTKMT2A
SCHEMBL9767710 0.69 CES2 (0.53) NPC1RAB9AMAPTALOX15HTT
SCHEMBL8075335 0.67 CES2 (0.55) NPC1RAB9AMAPTALOX15HTT
SCHEMBL6587159 0.67 MET (0.37) ATMNPC1RAB9AMAPTMEN1
SCHEMBL4852479 0.66 HTR2A (0.44) RAB9AMAPTMEN1KMT2A
SCHEMBL31393772 0.66 NR3C2 (0.55) NPC1RAB9AMAPTMEN1GAA
SCHEMBL6590586 0.65 PDE5A (0.43) TTKMAPTMEN1MAPK1HTT
SCHEMBL6590857 0.65 RAF1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1071701-A4 NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF ARENA PHARM INC (US) 2004-04-21 EP disclosed
EP-1071701-A1 NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF Arena Pharmaceuticals, Inc. (US) 2001-01-31 EP disclosed
WO-1999052927-A1 NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF ARENA PHARMACEUTICALS, INC. (US) 1999-10-21 WO disclosed