Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570833 | 0.85 | TAAR1 (0.50) | TAAR1IDO1ACHEHRH3MAOB | |
| SCHEMBL20198221 | 0.80 | TAAR1 (0.46) | TAAR1IDO1ACHEHRH3MAOB | |
| SCHEMBL13362473 | 0.79 | TP53 (0.41) | IDO1ALDH1A1 | |
| SCHEMBL10381187 | 0.78 | PNMT (0.50) | TAAR1IDO1 | |
| SCHEMBL21928925 | 0.78 | TAAR1 (0.47) | TAAR1IDO1MAOBALDH1A1TDP1 | |
| SCHEMBL16177052 | 0.78 | MAOB (0.48) | MAOBCYP11B1CYP11B2ALDH1A1TDP1 | |
| SCHEMBL776678 | 0.78 | TAAR1 (0.47) | TAAR1IDO1ACHEMAOBMEN1 | |
| SCHEMBL40995 | 0.75 | TP53 (0.43) | TAAR1IDO1MAOBALDH1A1TDP1 | |
| SCHEMBL15579733 | 0.75 | TP53 (0.43) | TAAR1IDO1MAOBALDH1A1TDP1 | |
| SCHEMBL3387191 | 0.75 | TP53 (0.43) | TAAR1IDO1MAOBALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-B1 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARM INC (US) | 2004-02-18 | — | — | EP | claimed |
| US-20170217949-A1 | 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| US-9669034-B2 | 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9499492-B2 | 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-11-22 | — | — | US | disclosed |
| US-20150291537-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-15 | — | — | US | disclosed |
| US-9133171-B2 | Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-09-15 | — | — | US | disclosed |
| US-20150005329-A1 | DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-01-01 | — | — | US | disclosed |
| US-20140315906-A1 | 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217949-A1 | 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP | PAH, NAT1, SULT2A1 | TAAR1 402/4885IDO1 18/4885ACHE 3921/4885 |
| US-20140315906-A1 | 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP | PAH, NAT1, SULT2A1 | TAAR1 402/4885IDO1 18/4885ACHE 3921/4885 |
| US-20150005329-A1 | DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | DHFR, DPYD, TYMP | TAAR1 3789/4885IDO1 438/4885ACHE 4505/4885 |
| US-20150291537-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP | OAT, PNPO, APOB | TAAR1 2109/4885IDO1 147/4885ACHE 2397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.