Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SELL | P14151 | 1/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.50 |
| ▸ | SELE | P16581 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28794852 | 0.86 | SELL (0.58) | SELLSELPSELEACHETP53 | |
| SCHEMBL156826 | 0.80 | RAPGEF4 (0.45) | SELLSELPSELEACHETP53 | |
| SCHEMBL23602095 | 0.79 | CYP3A4 (0.46) | ACHETDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL30279766 | 0.79 | CYP3A4 (0.46) | ACHETDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL1109753 | 0.77 | RAPGEF4 (0.43) | TP53TDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL28498020 | 0.76 | PTPN1 (0.43) | SELLSELPSELEACHETP53 | |
| SCHEMBL7511995 | 0.75 | SELL (0.46) | SELLSELPSELEACHETP53 | |
| SCHEMBL31088800 | 0.75 | PTGS1 (0.38) | TP53TDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL24724647 | 0.75 | PTGS1 (0.38) | TP53TDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL8761509 | 0.74 | SELL (0.50) | SELLSELPSELEACHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478199-A | Bimetallic catalyst and preparation method thereof, and preparation method of high molecular weight olefin polymer | 万华化学集团股份有限公司 | 2023-07-25 | — | — | CN | claimed |
| EP-4638438-A1 | ALPHA4 BETA7 INTEGRIN ANTAGONISTS AND USES THEREOF | Xinthera, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| US-12398136-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-08-26 | — | — | US | disclosed |
| US-12331048-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-06-17 | — | — | US | disclosed |
| US-12312351-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-05-27 | — | — | US | disclosed |
| CN-119137121-A | Pyrido- [3,4-d ] pyridazinamine derivatives useful as NLRP3 derivatives | 万特斯治疗美国公司 | 2024-12-13 | — | — | CN | disclosed |
| US-20240409540-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U S INC (US) | 2024-12-12 | — | — | US | disclosed |
| US-20240383896-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U.S., INC. | 2024-11-21 | — | — | US | disclosed |
| US-20240360130-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U.S., INC. | 2024-10-31 | — | — | US | disclosed |
| US-20240327413-A1 | NLRP3 MODULATORS | ZOMAGEN BIOSCIENCES LTD | 2024-10-03 | — | — | US | disclosed |
| US-20070099990-A1 | Cannabinoid receptor modulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-05-03 | — | — | US | disclosed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| EP-1637527-A1 | CANNABINOID RECEPTOR MODULATOR | Takeda Pharmaceutical Company Limited (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |
| US-20050037925-A1 | 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same | SANKYO AGRO COMPANY, LIMITED (JP) | 2005-02-17 | — | — | US | disclosed |
| EP-1426365-A1 | 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME | Sankyo Agro Company, Limited (JP) | 2004-06-09 | — | — | EP | disclosed |
| US-20030065021-A1 | Tracheal smooth muscle relaxants | YAMASHITA SHINYA (JP) | 2003-04-03 | — | — | US | disclosed |
| US-6495592-B1 | DIBENZ(B,F)OXEPIN DERIVATIVES; ANTIASTHMATICS | NIPPON SUISAN KAISHA, LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| US-6180659-B1 | USING A DIBENZO(B,F)-(OXEPIN OR THIEPIN) COMPOUND | NIPPON SUISAN KAISHA, LTD. (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0885610-A1 | TRACHEAL SMOOTH MUSCLE RELAXANT | NIPPON SUISAN KAISHA, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240383896-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | SELL 4492/4885SELP 3624/4885SELE 4786/4885 |
| US-12331048-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | NLRP3, NLRP1, NOD1 | SELL 4492/4885SELP 3624/4885SELE 4786/4885 |
| US-20240360130-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | SELL 4577/4885SELP 3857/4885SELE 4806/4885 |
| US-20240327413-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, NOD1 | SELL 3477/4885SELP 1314/4885SELE 2869/4885 |
| US-20030065021-A1 | Tracheal smooth muscle relaxants | MYLK, MUSK, CPT1B | SELL 3912/4885SELP 4409/4885SELE 3879/4885 |
| US-12398136-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | NLRP3, NLRP1, NOD1 | SELL 4492/4885SELP 3624/4885SELE 4786/4885 |
| US-20240409540-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | SELL 4492/4885SELP 3624/4885SELE 4786/4885 |
| US-20070099990-A1 | Cannabinoid receptor modulator | CNR1, CNR2, GPR18 | SELL 3797/4885SELP 3962/4885SELE 4037/4885 |
| US-12312351-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | NLRP3, NLRP1, NOD1 | SELL 4492/4885SELP 3624/4885SELE 4786/4885 |
| US-20050037925-A1 | 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same | CBR3, DDT, CHRM2 | SELL 4880/4885SELP 4870/4885SELE 4884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.