Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SELL | P14151 | 1/20 | 0.46 |
| ▸ | SELP | P16109 | 1/20 | 0.46 |
| ▸ | SELE | P16581 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449520 | 0.82 | ALDH1A1 (0.38) | KMT2AMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL28794852 | 0.82 | SELL (0.58) | SELLSELPSELEACHEKMT2A | |
| SCHEMBL13550094 | 0.75 | RAPGEF4 (0.39) | KMT2AMAPTALDH1A1LMNATSHR | |
| SCHEMBL7724614 | 0.75 | HPGD (0.56) | SELLSELPSELEACHEKMT2A | |
| SCHEMBL6841589 | 0.75 | SELL (0.65) | SELLSELPSELEACHEKMT2A | |
| SCHEMBL17864586 | 0.75 | ACHE (0.65) | SELLSELPSELEACHEKMT2A | |
| SCHEMBL659541 | 0.75 | SELL (0.50) | SELLSELPSELEACHEKMT2A | |
| SCHEMBL7033501 | 0.74 | LMNA (0.45) | SELLSELPSELEACHEKMT2A | |
| SCHEMBL28126392 | 0.73 | HSD17B10 (0.42) | ACHEKMT2AMAPTALDH1A1GAA | |
| SCHEMBL11398028 | 0.72 | HSD17B10 (0.46) | KMT2AMAPTALDH1A1RECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1234693-C | Indazol compound for inhibiting protein kinase and medicine composition and their application | AGOURON PHARMA (US) | 2006-01-04 | — | — | CN | disclosed |
| CN-1495171-A | Indazol compound for inhibiting protein kinase and medicine composition and their application | ������ҩ������˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1137884-C | Indazole compounds and pharmaceutical compositions that inhibit protein kinases and methods of use thereof | ������ҩ������˾ | 2004-02-11 | — | — | CN | disclosed |
| CN-1374950-A | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and their use | AGOURON PHARMACETUICALS INC (US) | 2002-10-16 | — | — | CN | disclosed |
| EP-1218348-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001002369-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |