Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | PPARA | Q07869 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxyacetic Acid SCHEMBL7624068 | 0.88 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10POLBPPARA | |
| SCHEMBL1045767 | 0.85 | KDM4E (0.62) | ALDH1A1KDM4EHSD17B10POLBPPARA | |
| SCHEMBL11939834 | 0.83 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10POLBPPARA | |
| SCHEMBL11946921 | 0.83 | KDM4E (0.55) | ALDH1A1KDM4EHSD17B10POLBPPARA | |
| SCHEMBL3608367 | 0.80 | FBP1 (0.52) | ALDH1A1POLBPPARAMAPTCYP1A2 | |
| SCHEMBL23871139 | 0.79 | PPARA (0.55) | ALDH1A1KDM4EHSD17B10PPARAMAPT | |
| SCHEMBL3590160 | 0.79 | POLB (0.42) | ALDH1A1KDM4EHSD17B10POLBMAPT | |
| SCHEMBL31606753 | 0.77 | TRPA1 (0.46) | ALDH1A1KDM4EPOLBMAPTMEN1 | |
| SCHEMBL147382 | 0.77 | MAPT (0.47) | ALDH1A1KDM4EPOLBMAPTMEN1 | |
| SCHEMBL11811333 | 0.76 | POLB (0.45) | ALDH1A1POLBPPARAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103965147-B | Benzofuran derivatives | 武田药品工业株式会社 | 2016-08-24 | — | — | CN | disclosed |
| CN-103242192-B | The inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 type enzyme | ABBVIE INC. (US) | 2016-05-04 | — | — | CN | disclosed |
| EP-2269977-B1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme | ABBVIE INC (US) | 2016-04-27 | — | — | EP | disclosed |
| US-9290444-B2 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | ABBVIE INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20150065508-A1 | INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBVIE INC. (US) | 2015-03-05 | — | — | US | disclosed |
| US-8957069-B2 | Benzofuran derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-17 | — | — | US | disclosed |
| EP-2781513-A1 | Benzofuran derivatives | Takeda Pharmaceutical Company Limited (JP) | 2014-09-24 | — | — | EP | disclosed |
| CN-103965147-A | Benzofuran derivatives | TAKEDA PHARMACEUTICAL | 2014-08-06 | — | — | CN | disclosed |
| CN-102421767-B | Benzofuran derivatives | TAKEDA PHARMACEUTICAL | 2014-06-18 | — | — | CN | disclosed |
| EP-2406243-B1 | BENZOFURAN DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2014-05-07 | — | — | EP | disclosed |
| US-20090023800-A1 | Cannabinoid receptor modulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2009-01-22 | — | — | US | disclosed |
| US-7465815-B2 | Cannabinoid receptor modulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-16 | — | — | US | disclosed |
| US-20080021087-A1 | Cannabinoid receptor modulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2008-01-24 | — | — | US | disclosed |
| EP-1846363-A2 | ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2007-10-24 | — | — | EP | disclosed |
| US-20070099990-A1 | Cannabinoid receptor modulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-05-03 | — | — | US | disclosed |
| US-20060281773-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | ABBVIE INC. | 2006-12-14 | — | — | US | disclosed |
| WO-2006074244-A2 | ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2006-07-13 | — | — | WO | disclosed |
| WO-2006058199-A1 | METHODS OF MODULATING HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS AND PHARMACEUTICAL FORMULATIONS FOR THE SAME | FAZIX CORPORATION (US) | 2006-06-01 | — | — | WO | disclosed |
| US-20060111346-A1 | Methods of modulating high-density lipoprotein cholesterol levels and pharmaceutical formulations for the same | FAZIX CORPORATION. | 2006-05-25 | — | — | US | disclosed |
| EP-1637527-A1 | CANNABINOID RECEPTOR MODULATOR | Takeda Pharmaceutical Company Limited (JP) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281773-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | HSD11B1, HSD17B1, HSD11B2 | ALDH1A1 156/4885KDM4E 3375/4885HSD17B10 11/4885 |
| US-20150065508-A1 | INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 177/4885KDM4E 3410/4885HSD17B10 11/4885 |
| US-20080021087-A1 | Cannabinoid receptor modulator | CNR1, CNR2, GPR18 | ALDH1A1 1463/4885KDM4E 737/4885HSD17B10 727/4885 |
| US-20060111346-A1 | Methods of modulating high-density lipoprotein cholesterol levels and pharmaceutical formulations for the same | HDLBP, LDLR, CETP | ALDH1A1 3198/4885KDM4E 2223/4885HSD17B10 457/4885 |
| US-20090023800-A1 | Cannabinoid receptor modulator | CNR1, CNR2, GPR18 | ALDH1A1 1463/4885KDM4E 737/4885HSD17B10 727/4885 |
| US-20070099990-A1 | Cannabinoid receptor modulator | CNR1, CNR2, GPR18 | ALDH1A1 1463/4885KDM4E 737/4885HSD17B10 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.