Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545417 | 0.84 | CASP6 (0.48) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL1109931 | 0.83 | ALOX5 (0.46) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL31290232 | 0.83 | POLB (0.47) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL4886000 | 0.83 | POLB (0.47) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL3332527 | 0.83 | POLB (0.57) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL5637840 | 0.79 | ALDH1A1 (0.50) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL29518510 | 0.79 | ALDH1A1 (0.50) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL20564544 | 0.79 | CYP1A2 (0.42) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL22658046 | 0.79 | TRPM4 (0.42) | POLBTRPM4ALDH1A1HIF1ACYP1B1 | |
| SCHEMBL31590404 | 0.79 | TRPM4 (0.42) | POLBTRPM4ALDH1A1HIF1ACYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968163-A1 | PROCESS FOR THE MANUFACTURE OF 2-BROMO-6-METHOXYNAPHTHALENE | Bromine Compounds Ltd. (IL) | 2000-01-05 | — | — | EP | claimed |
| WO-1998042647-A1 | PROCESS FOR THE MANUFACTURE OF 2-BROMO-6-METHOXYNAPHTHALENE | BROMINE COMPOUNDS LTD. (IL) | 1998-10-01 | — | — | WO | claimed |
| WO-2023125627-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | LYNK PHARMACEUTICALS CO., LTD. (CN) | 2023-07-06 | — | — | WO | disclosed |
| US-20230059136-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-02-23 | — | — | US | disclosed |
| EP-3880658-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | Novartis AG (CH) | 2021-09-22 | — | — | EP | disclosed |
| CN-113227055-A | Compounds and compositions for treating conditions associated with NLRP activity | 诺华股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-1432689-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | Bayer Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027074-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
| EP-0968163-A1 | PROCESS FOR THE MANUFACTURE OF 2-BROMO-6-METHOXYNAPHTHALENE | Bromine Compounds Ltd. (IL) | 2000-01-05 | — | — | EP | disclosed |
| EP-0937021-A1 | PRODUCTION OF NABUMETONE OR PRECURSORS THEREOF | ALBEMARLE CORPORATION (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5907069-A | METHYLATION OF 6-BROMO-2-NAPHTHOL WITH METHYL BROMIDE OR METHYL CHLORIDE AND RECOVERING NABUMETONE | ALBEMARLE CORPORATION (US) | 1999-05-25 | — | — | US | disclosed |
| WO-1998042647-A1 | PROCESS FOR THE MANUFACTURE OF 2-BROMO-6-METHOXYNAPHTHALENE | BROMINE COMPOUNDS LTD. (IL) | 1998-10-01 | — | — | WO | disclosed |
| US-5792886-A | METHYLATION OF 6-BROMO-2-NAPHTHOL WITH METHYL BROMIDE TO 2-BROMO-6-METHOXYNAPHTHALENE; FORMING GRIGNARD; REACTING WITH A LOWER ALKYL 2-BROMOPROPIONATE | ALBEMARLE CORPORATION (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998030528-A2 | PRODUCTION OF RACEMIC 2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID OR PRECURSORS THEREOF | ALBEMARLE CORPORATION (US) | 1998-07-16 | — | — | WO | disclosed |
| US-5756851-A | Production of nabumetone or precursors thereof | ALBEMARLE CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| WO-1998017616-A1 | PRODUCTION OF NABUMETONE OR PRECURSORS THEREOF | ALBEMARLE CORPORATION (US) | 1998-04-30 | — | — | WO | disclosed |
| US-3960972-A | FROM OLEFINS AND FORMALDEHYDE, PHENOL PROMOTER | PHILLIPS PETROLEUM COMPANY (US) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | POLB 749/4885TRPM4 4733/4885ALDH1A1 758/4885 |
| US-20230059136-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NLRP1, NLRP3, NOD1 | POLB 4588/4885TRPM4 417/4885ALDH1A1 2123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.