Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391079 | 0.81 | CES2 (0.35) | ATMALDH1A1CA2KMT2AHPGD | |
| SCHEMBL27562903 | 0.76 | KDM4E (0.38) | KDM4EATML3MBTL1LDHASMN1; SMN2 | |
| SCHEMBL6803138 | 0.75 | KMT2A (0.36) | ALDH1A1KMT2A | |
| SCHEMBL7819980 | 0.74 | KDM4E (0.42) | KDM4ELDHACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL28048096 | 0.73 | RAB9A (0.42) | ATMSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL24377922 | 0.73 | KDM4E (0.36) | KDM4EATML3MBTL1LDHASMN1; SMN2 | |
| SCHEMBL9739474 | 0.72 | L3MBTL1 (0.37) | KDM4EATML3MBTL1LDHASMN1; SMN2 | |
| SCHEMBL1255217 | 0.72 | ATM (0.39) | KDM4EATML3MBTL1LDHASMN1; SMN2 | |
| SCHEMBL28941715 | 0.72 | ATM (0.50) | KDM4EATML3MBTL1LDHAMAPK13 | |
| SCHEMBL28384726 | 0.71 | MAPT (0.44) | KDM4EL3MBTL1LDHASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-A2 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | NOVO NORDISK A/S (DK) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003004480-A2 | SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS | NOVO NORDISK A/S (DK) | 2003-01-16 | — | — | WO | disclosed |