Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 11/20 | 0.37 |
| ▸ | CTSS | P25774 | 8/20 | 0.37 |
| ▸ | CTSB | P07858 | 6/20 | 0.37 |
| ▸ | CTSV | O60911 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213602 | 0.88 | CTSK (0.39) | CTSKRAB9ANPC1TP53PKM | |
| SCHEMBL6673927 | 0.87 | CTSK (0.39) | CTSKRAB9ANPC1TP53PKM | |
| SCHEMBL6211960 | 0.80 | CTSK (0.40) | CTSKRAB9ANPC1TP53PKM | |
| SCHEMBL6599127 | 0.79 | PBK (0.33) | — | |
| SCHEMBL6604897 | 0.78 | HTR6 (0.31) | — | |
| Hydrochloric Acid SCHEMBL5101404 | 0.73 | RAB9A (0.47) | RAB9ANPC1TP53PKMSMN1; SMN2 | |
| SCHEMBL6590467 | 0.73 | CTSK (0.42) | CTSKRAB9ANPC1TP53PKM | |
| SCHEMBL6211256 | 0.72 | RAB9A (0.31) | RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL7538204 | 0.72 | TAS1R3 (0.49) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7426386 | 0.72 | RAB9A (0.45) | CTSKRAB9ANPC1TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392657-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-03-10 | — | — | EP | claimed |
| EP-1392657-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-03 | — | — | EP | claimed |
| WO-2003053331-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-03 | — | — | WO | claimed |
| EP-1392657-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-03-10 | — | — | EP | disclosed |
| EP-1392657-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003053331-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |