Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660680 | 0.83 | RAB9A (0.49) | MAPK8SIGMAR1RAB9ASRCPOLB | |
| SCHEMBL7965958 | 0.81 | RAB9A (0.51) | KMT2ARAB9APOLBALDH1A1TP53 | |
| SCHEMBL6863580 | 0.80 | CES2 (0.46) | KMT2AMEN1MAPK8SIGMAR1CES2 | |
| SCHEMBL5907106 | 0.79 | MEN1 (0.41) | KMT2AMEN1MAPK8SIGMAR1CES2 | |
| SCHEMBL4662034 | 0.78 | TACR1 (0.40) | KMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL3563691 | 0.76 | METAP2 (0.47) | KMT2AMEN1RIPK1CES2CES1 | |
| SCHEMBL6349425 | 0.76 | CTSS (0.40) | KMT2AMEN1MAPK8SIGMAR1ALDH1A1 | |
| SCHEMBL4659342 | 0.75 | MMP13 (0.48) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4660654 | 0.75 | KMT2A (0.42) | KMT2AMEN1RAB9AALDH1A1TP53 | |
| SCHEMBL4582402 | 0.75 | CES1 (0.52) | KMT2AMEN1CES2CES1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395251-A2 | AMINEDIOLS AS AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002100818-A2 | AMINEDIOLS AS AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |