Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960584 | 0.85 | CTSD (0.51) | ADRA1DADRA1AADRA1BGAAJAK2 | |
| SCHEMBL8096449 | 0.85 | ADRA1D (0.59) | ADRA1DADRA1AADRA1BGAAJAK2 | |
| SCHEMBL2001238 | 0.82 | FABP4 (0.48) | ADRA1DADRA1AADRA1BGAAJAK2 | |
| SCHEMBL6088062 | 0.81 | JAK2 (0.48) | ADRA1DADRA1AADRA1BGAAJAK2 | |
| SCHEMBL184136 | 0.81 | ALDH1A1 (0.62) | PLK1POLBFABP4KDM4EKMT2A | |
| SCHEMBL12386087 | 0.81 | MEN1 (0.59) | JAK2JAK1KDM4EKMT2AALDH1A1 | |
| SCHEMBL28644608 | 0.81 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BGAAPLK1 | |
| SCHEMBL2061071 | 0.80 | POLB (0.62) | ADRA1DADRA1AADRA1BGAAPLK1 | |
| SCHEMBL1532856 | 0.80 | KMT2A (0.58) | GAAPOLBFABP4KDM4EKMT2A | |
| SCHEMBL11520956 | 0.79 | FABP4 (0.49) | ADRA1DADRA1AADRA1BGAAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036075-B1 | SUBSTITUTED THIAZOLIDINEDIONE AND OXAZOLIDINEDIONE HAVING ANTIDIABETIC, HYPOLIPIDEMIA AND ANTIHYPERTENSIVE PROPERTIES | REDDYS LAB LTD DR (IN) | 2004-06-23 | — | — | EP | disclosed |
| US-6313113-B1 | AZOLIDINEDIONE DERIVATIVES, ANALOGUES, TAUTOMERIC FORMS, STEREOISOMERS, POLYMORPHS, SALTS AND SOLVATES; TREATING NON-INSULIN-DEPENDENT DIABETES MELLITUS | REDDY-CHEMINOR, INC. | 2001-11-06 | — | — | US | disclosed |
| US-6030973-A | TYPE II DIABETES (NON-INSULIN-DEPENDENT-DIABETES MELLITUS) POTENTIATION; EFFICIENCY; SIDE EFFECT REDUCTION | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-02-29 | — | — | US | disclosed |