Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610605 | 0.92 | ACHE (0.49) | BCHEACHENPC1RAB9ANPY5R | |
| SCHEMBL6616272 | 0.89 | BCHE (0.47) | BCHEACHENPC1RAB9AALDH1A1 | |
| SCHEMBL6613611 | 0.87 | ACHE (0.42) | BCHEACHENPC1RAB9AALDH1A1 | |
| SCHEMBL6610332 | 0.86 | BCHE (0.49) | BCHEACHENPC1RAB9ACHRNA7 | |
| SCHEMBL6609478 | 0.86 | BCHE (0.48) | BCHEACHENPC1RAB9AALDH1A1 | |
| SCHEMBL6609227 | 0.86 | BCHE (0.55) | BCHEACHENPC1RAB9ACHRNA7 | |
| SCHEMBL6611305 | 0.86 | BCHE (0.59) | BCHEACHENPC1RAB9ACHRNA7 | |
| SCHEMBL5842752 | 0.82 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAKDM4EMEN1 | |
| SCHEMBL6609671 | 0.79 | BCHE (0.47) | BCHEACHENPC1RAB9AALDH1A1 | |
| SCHEMBL6611149 | 0.79 | MGLL (0.57) | BCHEACHENPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |