Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 10/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | BRD4 | O60885 | 1/20 | 0.68 |
| ▸ | IKBKB | O14920 | 1/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618581 | 0.88 | TUBB4A (0.67) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL6613017 | 0.85 | TERT (0.88) | TERTCYP3A4ALDH1A1MAPTMEN1 | |
| SCHEMBL31322174 | 0.84 | TERT (1.00) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL4649959 | 0.84 | TERT (1.00) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL1778286 | 0.84 | TERT (1.00) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL6614126 | 0.84 | TERT (1.00) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL6613428 | 0.84 | TERT (0.81) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL6618127 | 0.82 | TERT (0.78) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| SCHEMBL6802044 | 0.82 | TERT (0.77) | TERTCYP3A4ALDH1A1MAPTTP53 | |
| 7,8-Dihydroxyflavone SCHEMBL419316 | 0.81 | TERT (1.00) | TERTCYP3A4ALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063665-A1 | Substituted benzopyranones as telomerase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2004-04-01 | — | — | US | disclosed |
| EP-1373244-A2 | SUBSTITUTED BENZOPYRANONES AS TELOMERASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-02 | — | — | EP | disclosed |
| US-20020160983-A1 | Substituted benzopyranones as telomerase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2002-10-31 | — | — | US | disclosed |
| WO-2002074036-A2 | SUBSTITUTED BENZOPYRANONES AS TELOMERASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160983-A1 | Substituted benzopyranones as telomerase inhibitors | TERT, TERF2, TERF2IP | TERT 1/4885CYP3A4 3385/4885ALDH1A1 1247/4885 |
| US-20040063665-A1 | Substituted benzopyranones as telomerase inhibitors | TERT, TERF2, TERF2IP | TERT 1/4885CYP3A4 3411/4885ALDH1A1 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.