SCHEMBL662843

SCHEMBL662843

CC(N)OC=C(c1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.36
ADRA2A P08913 1/20 0.36
ADRA2C P18825 1/20 0.36
HIF1A Q16665 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 2/20 0.35
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
TAAR1 Q96RJ0 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
TSHR P16473 1/20 0.33
ANPEP P15144 1/20 0.33
LAP3 P28838 1/20 0.33
MAOA P21397 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
SIGMAR1 Q99720 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22723010 0.74 KMT2A (0.40) LMNAKDM4EALDH1A1PDE4APDE4B
SCHEMBL28728329 0.72 TSHR (0.44) LMNAKDM4EALDH1A1PDE4APDE4B
SCHEMBL1827690 0.71 ALDH1A1 (0.41) LMNAALDH1A1PDE4APDE4BPDE4C
SCHEMBL22723014 0.70 MEN1 (0.37) LMNAKDM4EALDH1A1PDE4APDE4B
SCHEMBL22753319 0.68 CES2 (0.45) KDM4EALDH1A1PDE4APDE4BPDE4C
SCHEMBL6935684 0.67 ESR1 (0.43) LMNAALDH1A1NPSR1TSHRCYP1A2
SCHEMBL6548505 0.67 TDP1 (0.42) LMNAALDH1A1PDE4APDE4BPDE4C
SCHEMBL10437667 0.67 CYP19A1 (0.39) LMNAALDH1A1PDE4APDE4BPDE4C
SCHEMBL660285 0.67 MTNR1A (0.39) LMNAALDH1A1PDE4APDE4BPDE4C
SCHEMBL10606928 0.67 CYP1B1 (0.40) LMNAALDH1A1PDE4APDE4BPDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120046492-A1 Ethoxy Diphenyl Ethane Derivatives, Preparation Processes and Uses Thereof Zhejiang Wild Wind Pharmaceutical Co., Ltd. (CN) 2012-02-23 US disclosed
EP-2351730-A1 ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF Shanghai Ecust Biomedicine Co., Ltd (CN) 2011-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046492-A1 Ethoxy Diphenyl Ethane Derivatives, Preparation Processes and Uses Thereof TUBB1, TUBB, TUBB3 LMNA 1662/4885ADRA2A 1801/4885ADRA2C 1988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.