Sugi Predict

Sugi Predict / Compounds / SCHEMBL663238

SCHEMBL663238

SCHEMBL663238

O=[N+]([O-])c1cccc2occc12

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 3/20 0.57
▸ MEN1 O00255 2/20 0.53
▸ GAA P10253 2/20 0.53
▸ KMT2A Q03164 2/20 0.53
▸ MAPT P10636 1/20 0.53
▸ ALDH1A1 P00352 5/20 0.50
▸ PAX8 Q06710 1/20 0.49
▸ GPR35 Q9HC97 2/20 0.45
▸ POLB P06746 1/20 0.43
▸ MAOA P21397 1/20 0.42
▸ MAOB P27338 1/20 0.42
▸ FTO Q9C0B1 1/20 0.42
▸ NOS1 P29475 1/20 0.42
▸ TSHR P16473 2/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.40
▸ NCOA1 Q15788 1/20 0.40
▸ NCOA3 Q9Y6Q9 1/20 0.40
▸ S100A4 P26447 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL305604 0.78 TDP1 (0.64) TDP1MEN1GAAKMT2AMAPT
SCHEMBL8081425 0.74 TDP1 (0.48) TDP1MEN1GAAKMT2AMAPT
SCHEMBL9149685 0.74 MAPT (0.58) TDP1MEN1GAAKMT2AMAPT
SCHEMBL29475175 0.74 TDP1 (1.00) TDP1GAAALDH1A1GPR35POLB
SCHEMBL57166 0.74 TDP1 (1.00) TDP1GAAALDH1A1GPR35POLB
SCHEMBL28093598 0.72 TDP1 (0.95) TDP1MEN1GAAKMT2AMAPT
SCHEMBL3276135 0.71 MAOA (0.54) TDP1MEN1KMT2AMAPTALDH1A1
SCHEMBL6364597 0.70 TDP1 (0.59) TDP1MEN1GAAKMT2AMAPT
SCHEMBL31290996 0.69 GPR35 (0.52) TDP1MEN1GAAKMT2AMAPT
SCHEMBL20125060 0.69 MAPT (0.66) TDP1MEN1GAAKMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220378766-A1 MODULATING EXPRESSION LEVEL OF A GENE ENCODING AN UNCOUPLING PROTEIN BY TREATING A HUMAN SUBJECT WITH A NITROXIDE HABASH LOUIS (US) 2022-12-01 — — US claimed
CN-104530064-B Preparation method of colorimetric mercury ion sensor based on rhodamine derivative and application 湖南科技大学 2017-02-22 — — CN claimed
US-5728714-A Method for treating hair loss using tempo PROCTOR PETER H (US) 1998-03-17 — — US claimed
EP-4123737-B1 ORGANOELECTROLUMINESCENT DEVICE USING POLYCYCLIC AROMATIC COMPOUNDS SFC CO LTD (KR) 2025-07-30 — — EP disclosed
US-11998536-B2 Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide HABASH LOUIS (US) 2024-06-04 — — US disclosed
CN-114315773-B Piperazine compound and preparation method thereof 广东东阳光药业股份有限公司 2024-01-16 — — CN disclosed
CN-117304196-A Spiro [ benzofuran-tetrahydropyrrole ] compound, preparation method and application thereof 三峡大学 2023-12-29 — — CN disclosed
US-11839606-B2 Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide HABASH LOUIS (US) 2023-12-12 — — US disclosed
US-11819500-B2 T-cell regulation in t-cell mediated diseases by reducing pathogenic function of TH17 in a human subject through treatment with a nitroxide HABASH LOUIS (US) 2023-11-21 — — US disclosed
US-20230232650-A1 ORGANOELECTROLUMINESCENT DEVICE USING POLYCYCLIC AROMATIC COMPOUNDS SFC CO., LTD (KR) 2023-07-20 — — US disclosed
CN-116283868-A Synthesis method of spiro [ benzofuran-cyclohexene ] compound 三峡大学 2023-06-23 — — CN disclosed
WO-2004009557-A1 6-AMINO-1H-INDAZOLE AND 4-AMINOBENZOFURAN COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2004-01-29 — — WO disclosed
EP-1089734-A2 USE OF TEMPO AND TEMPO DERIVATIVES FOR INDUCING CELL DEATH Georgetown University Medical Center (US) 2001-04-11 — — EP disclosed
WO-2000000157-A2 USE OF TEMPO AND TEMPO DERIVATIVES FOR INDUCING CELL DEATH GEORGETOWN UNIVERSITY MEDICAL CENTER (US) 2000-01-06 — — WO disclosed
US-5728714-A Method for treating hair loss using tempo PROCTOR PETER H (US) 1998-03-17 — — US disclosed
US-5352442-A Topical tempo PROCTOR PETER H (US) 1994-10-04 — — US disclosed
EP-0079683-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-05-06 — — EP disclosed
US-4514211-A HERBICIDES, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-30 — — US disclosed
EP-0079683-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-05-25 — — EP disclosed
US-3963717-A ANTIINFLAMMATORY, ANALGESIC SANDOZ, INC. (US) 1976-06-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11998536-B2 Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide PSMD4, PSMD2, PSMD1 TDP1 933/4885MEN1 4313/4885GAA 760/4885
US-20220378766-A1 MODULATING EXPRESSION LEVEL OF A GENE ENCODING AN UNCOUPLING PROTEIN BY TREATING A HUMAN SUBJECT WITH A NITROXIDE TXNRD2, TXN2, TXNRD3 TDP1 2140/4885MEN1 4590/4885GAA 3926/4885
US-11819500-B2 T-cell regulation in t-cell mediated diseases by reducing pathogenic function of TH17 in a human subject through treatment with a nitroxide CD4, NFATC1, CD58 TDP1 1847/4885MEN1 2979/4885GAA 4131/4885
US-11839606-B2 Increasing expression level of apoptosis-related genes by treating a human subject with a nitroxide CCAR2, DCLRE1B, DDIT3 TDP1 264/4885MEN1 4238/4885GAA 3252/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.