Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814264 | 0.89 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL7393652 | 0.89 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL379160 | 0.89 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL3970912 | 0.89 | MEN1 (0.76) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| Bicarbonate SCHEMBL4357688 | 0.87 | MEN1 (0.73) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL15011579 | 0.87 | MEN1 (0.73) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL15447435 | 0.86 | MEN1 (0.64) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL31596932 | 0.86 | SIGMAR1 (0.61) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL17084538 | 0.85 | MEN1 (0.63) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 | |
| SCHEMBL15709327 | 0.85 | L3MBTL1 (0.63) | MEN1KMT2ANPSR1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906543-B1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | UNIV ASTON (GB) | 2019-01-02 | — | — | EP | disclosed |
| EP-2906543-B1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | UNIV ASTON (GB) | 2019-01-02 | — | — | EP | disclosed |
| US-10017516-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-10017516-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-10017516-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2017-11-23 | — | — | US | disclosed |
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2017-11-23 | — | — | US | disclosed |
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2017-11-23 | — | — | US | disclosed |
| US-9682983-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682983-B2 | BMP inhibitors and methods of use thereof | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
| EP-2906543-A1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | Aston University (GB) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014160203-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014160203-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014057266-A1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | ASTON UNIVERSITY (GB) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014057266-A1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | ASTON UNIVERSITY (GB) | 2014-04-17 | — | — | WO | disclosed |
| EP-1446665-A2 | ISOTOPICALLY CODED AFFINITY MARKERS 3 | Bayer HealthCare AG (DE) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003040288-A2 | ISOTOPICALLY CODED AFFINITY MARKERS 3 | BAYER HEALTHCARE AG (DE) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ENPEP, ENPP2, MMP17 | MEN1 1690/4885KMT2A 1957/4885NPSR1 3162/4885 |
| US-20170334918-A1 | BMP Inhibitors and Methods of Use Thereof | BMP1, BMPR2, BMP2 | MEN1 514/4885KMT2A 3607/4885NPSR1 3174/4885 |
| US-10017516-B2 | BMP inhibitors and methods of use thereof | BMP1, BMPR2, BMP2 | MEN1 514/4885KMT2A 3607/4885NPSR1 3174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.