SCHEMBL6645809

SCHEMBL6645809

Cc1ccc(C(=O)Nc2ccc(N(CCc3cccc(NC(=O)OC(C)(C)C)n3)C(=O)OC(C)(C)C)cc2)c(Cl)n1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.34
GBA1 P04062 1/20 0.34
NR3C1 P04150 5/20 0.34
ITGB1 P05556 1/20 0.34
ITGA4 P13612 1/20 0.34
SORT1 Q99523 4/20 0.33
LCK P06239 2/20 0.33
CCR2 P41597 1/20 0.33
GLA P06280 1/20 0.33
TSHR P16473 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
NAMPT P43490 1/20 0.33
ACKR3 P25106 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
EGFR P00533 1/20 0.32
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645763 0.90 NPC1 (0.33) RAB9AGBA1ITGB1ITGA4SORT1
SCHEMBL6645220 0.86 NR3C1 (0.39) RAB9ANR3C1ALDH1A1EGFRNPC1
SCHEMBL6646133 0.84 KIF18A (0.39) ALDH1A1
SCHEMBL6828920 0.83 SORT1 (0.35) RAB9AGBA1SORT1LCKNAMPT
SCHEMBL6800939 0.83 GAA (0.42) ALDH1A1
SCHEMBL6800937 0.80 BCL2 (0.37) NAMPT
SCHEMBL6489886 0.80 NR3C2 (0.39) LCKCCR2
SCHEMBL6796042 0.80 MTTP (0.36) RAB9AALDH1A1MAPTNPC1
SCHEMBL6645223 0.79 F2 (0.39) RAB9AITGB1ITGA4SORT1ACKR3
SCHEMBL6792697 0.79 MTTP (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040133008-A1 Amide compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-07-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040133008-A1 Amide compounds APOB, APOL1, LDLR RAB9A 3028/4885GBA1 166/4885NR3C1 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.