Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | CFD | P00746 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649339 | 0.84 | MAOB (0.38) | CYP4F2CYP4A11MAOBALDH1A1GAA | |
| SCHEMBL27649172 | 0.83 | CYP4F2 (0.44) | CYP4F2CYP4A11CFDMAOBKDM4E | |
| SCHEMBL28055980 | 0.83 | PKM (0.37) | MAOBALDH1A1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL8216520 | 0.81 | CFD (0.49) | CYP4F2CYP4A11CFDKDM4EPTGS2 | |
| SCHEMBL21044063 | 0.81 | LMNA (0.48) | CYP4F2CYP4A11CFDMAOBKDM4E | |
| SCHEMBL2791448 | 0.79 | PTGS2 (0.52) | KDM4EPTGS2ALDH1A1TSHRBLM | |
| SCHEMBL3639665 | 0.79 | BACE1 (0.51) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL5755257 | 0.78 | TSHR (0.58) | CYP4F2CYP4A11CFDKDM4EPTGS2 | |
| SCHEMBL8897775 | 0.78 | CFD (0.39) | CYP4F2CYP4A11CFDKDM4EPTGS2 | |
| SCHEMBL27706038 | 0.77 | FFAR1 (0.46) | CYP4F2CYP4A11CFDKDM4EPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |