Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650657 | 0.84 | CYP4F2 (0.44) | MAOBPKMPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL27602868 | 0.82 | ALOX15 (0.36) | MAOBPKMSMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL9407039 | 0.80 | L3MBTL1 (0.39) | L3MBTL1SMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL11355453 | 0.78 | ALDH1A1 (0.40) | MAOBPKMSMN1; SMN2RIPK1ALDH1A1 | |
| SCHEMBL6649289 | 0.77 | FFAR1 (0.44) | PKMSMN1; SMN2ALDH1A1MAPTFFAR1 | |
| SCHEMBL5755250 | 0.76 | KDM4E (0.46) | POLBL3MBTL1ALDH1A1MAPTCYP4F2 | |
| SCHEMBL5740669 | 0.75 | CES2 (0.42) | MAOBPKML3MBTL1MAPT | |
| SCHEMBL28055980 | 0.74 | PKM (0.37) | MAOBPKMSMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL27674522 | 0.73 | CA3 (0.41) | MAOBPKMGAA | |
| SCHEMBL4374302 | 0.73 | PKM (0.62) | PKMPOLBL3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |