Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29438077 | 1.00 | ALDH1A1 (0.38) | ALDH1A1TRPA1POLBKDM4EPLAU | |
| SCHEMBL9264505 | 0.81 | — | — | |
| SCHEMBL10354420 | 0.80 | ALDH1A1 (0.39) | ALDH1A1POLBKDM4EPLAUSMN1; SMN2 | |
| SCHEMBL31547985 | 0.78 | AGBL2 (0.47) | ALDH1A1POLBKDM4EPLAUSMN1; SMN2 | |
| SCHEMBL31002183 | 0.78 | CYP11B2 (0.36) | RXRAGRIN1GRIN2B | |
| SCHEMBL609041 | 0.77 | ALDH1A1 (0.40) | ALDH1A1TRPA1POLBKDM4EPLAU | |
| SCHEMBL23746896 | 0.77 | ALDH1A1 (0.45) | ALDH1A1POLBKDM4EPLAUSMN1; SMN2 | |
| SCHEMBL18299209 | 0.77 | ALDH1A1 (0.42) | ALDH1A1POLBKDM4EPLAUSMN1; SMN2 | |
| SCHEMBL2596379 | 0.77 | ALDH1A1 (0.53) | ALDH1A1POLBKDM4EPLAUSMN1; SMN2 | |
| SCHEMBL30060619 | 0.77 | ALDH1A1 (0.45) | ALDH1A1POLBKDM4EPLAUSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568960-B1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2026-04-29 | — | — | EP | disclosed |
| US-20250236614-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-07-24 | — | — | US | disclosed |
| US-12351584-B2 | Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-07-08 | — | — | US | disclosed |
| US-20250154107-A1 | 3,4-Dihydroisoquinolin-1(2H)-Ones Derivatives as STING Antagonists and the Use Thereof | BEIGENE SWITZERLAND GMBH (CH) | 2025-05-15 | — | — | US | disclosed |
| US-20250034170-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2025-01-30 | — | — | US | disclosed |
| US-20240398781-A1 | SPIROCYCLIC CYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | CONVELO THERAPEUTICS, INC. | 2024-12-05 | — | — | US | disclosed |
| EP-4436975-A1 | SPIROCYCLIC CYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| EP-4415706-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2024033458-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | disclosed |
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | Grünenthal GmbH (DE) | 2023-09-28 | — | — | US | disclosed |
| EP-0097460-B1 | PYRIDYL(OXY/THIO)PHENOXY COMPOUNDS, HERBICIDAL COMPOSITIONS AND METHODS | THE DOW CHEMICAL COMPANY (US) | 1988-04-06 | — | — | EP | disclosed |
| US-4678509-A | GRASSY WEEDS | THE DOW CHEMICAL COMPANY (US) | 1987-07-07 | — | — | US | disclosed |
| US-4625035-A | 2,3-difluoro-5-(trifluoromethyl)pyridine | THE DOW CHEMICAL COMPANY (US) | 1986-11-25 | — | — | US | disclosed |
| US-4565568-A | Pyridyl(oxy/thio)phenoxy compounds, herbicidal compositions and methods | THE DOW CHEMICAL COMPANY (US) | 1986-01-21 | — | — | US | disclosed |
| US-4480102-A | 2,3-Difluoro-5-(trifluoromethyl)pyridine and methods of making and using the same | THE DOW CHEMICAL COMPANY (US) | 1984-10-30 | — | — | US | disclosed |
| EP-0034917-B1 | 2-SUBSTITUTED-5-TRIFLUOROMETHYLPYRIDINES AND A PROCESS FOR PRODUCING THE SAME | ISHIHARA SANGYO KAISHA LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |
| EP-0104715-A2 | 2,3-Difluoro-5-(trifluoromethyl)pyridine and method of making and using the same | THE DOW CHEMICAL COMPANY (US) | 1984-04-04 | — | — | EP | disclosed |
| EP-0097460-A1 | Pyridyl(oxy/thio)phenoxy compounds, herbicidal compositions and methods | THE DOW CHEMICAL COMPANY (US) | 1984-01-04 | — | — | EP | disclosed |
| US-4367336-A | 2-Substituted-5-trifluoromethylpyridines and process for producing the same | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1983-01-04 | — | — | US | disclosed |
| EP-0034917-A1 | 2-Substituted-5-trifluoromethylpyridines and a process for producing the same | ISHIHARA SANGYO KAISHA LTD. (JP) | 1981-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250034170-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | GBA1, GAA, GBA2 | ALDH1A1 1971/4885TRPA1 4016/4885POLB 1535/4885 |
| US-20230303573-A1 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | ALDH1A1 337/4885TRPA1 38/4885POLB 2650/4885 |
| US-20250236614-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | GRIN2C, CNR1, CNR2 | ALDH1A1 871/4885TRPA1 469/4885POLB 3866/4885 |
| US-20240398781-A1 | SPIROCYCLIC CYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | MAG, PMP22, NR1H2 | ALDH1A1 2545/4885TRPA1 4527/4885POLB 2847/4885 |
| US-12351584-B2 | Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide | CNP, PDE3A, PDE5A | ALDH1A1 344/4885TRPA1 2729/4885POLB 2037/4885 |
| US-20250154107-A1 | 3,4-Dihydroisoquinolin-1(2H)-Ones Derivatives as STING Antagonists and the Use Thereof | STING1, IRF3, MAVS | ALDH1A1 4770/4885TRPA1 735/4885POLB 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.