Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11363136 | 0.77 | KDM4E (0.47) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11363133 | 0.75 | KDM4E (0.46) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL637319 | 0.75 | RAB9A (0.52) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28047501 | 0.75 | KDM4E (0.46) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29754142 | 0.75 | RAB9A (0.52) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11725090 | 0.73 | KDM4E (0.45) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7005196 | 0.73 | KDM4E (0.49) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2469671 | 0.72 | RAB9A (0.53) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31141504 | 0.72 | CYP2D6 (0.47) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6162141 | 0.72 | CYP2D6 (0.47) | CYP2D6CYP2C19KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127461-A1 | Water soluble, randomly substituted partial N-, partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof | ADJUVANT PHARMACEUTICALS, LLC (US) | 2004-07-01 | — | — | US | claimed |
| EP-1425310-A2 | WATER SOLUBLE, RANDOMLY SUBSTITUTED PARTIAL N-, PARTIAL O-ACETYLATED CHITOSAN, PRESERVING COMPOSITIONS CONTAINING CHITOSAN, AND PROCESSES FOR MAKING THEREOF | Technology Resource International Corporation (US) | 2004-06-09 | — | — | EP | claimed |
| US-6716970-B2 | CONTACT LENS PRESERVATIVE SOLUTION | ADJUVANT PHARMACEUTICALS, LLC | 2004-04-06 | — | — | US | claimed |
| US-20020177577-A1 | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof | ADJUVANT PHARMACEUTICALS, LLC | 2002-11-28 | — | — | US | claimed |
| WO-2002085951-A2 | WATER SOLUBLE, RANDOMLY SUBSTITUTED PARTIAL N-, PARTIAL O-ACETYLATED CHITOSAN, PRESERVING COMPOSITIONS CONTAINING CHITOSAN, AND PROCESSES FOR MAKING THEREOF | TECHNOLOGY RESOURCE INTERNATIONAL CORPORATION (US) | 2002-10-31 | — | — | WO | claimed |
| US-20020018732-A1 | Preserving compositions containing chitosan and processes for making water soluble O-acetylated chitosan and chitosan | TECHNOLOGY RESOURCE INTERNATIONAL CORPORATION | 2002-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177577-A1 | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof | PIGS, CSGALNACT1, OGA | ACHE 886/4885CYP2D6 3305/4885CYP2C19 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.