Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570545 | 0.86 | PLA2G4A (0.47) | PDPK1TRPA1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL9247585 | 0.82 | FFAR2 (0.43) | TRPA1L3MBTL1MAPTLMNAKDM4E | |
| SCHEMBL3388731 | 0.79 | SMN1; SMN2 (0.40) | PDPK1MAOBALDH1A1MAPTPKM | |
| SCHEMBL8671010 | 0.75 | FDPS (0.38) | MAOBALDH1A1TSHRRIOK2HSD17B10 | |
| SCHEMBL28038637 | 0.71 | TRPA1 (0.42) | PDPK1TRPA1ALDH1A1MAPTPKM | |
| SCHEMBL1986516 | 0.71 | — | — | |
| SCHEMBL949287 | 0.71 | PDPK1 (0.45) | PDPK1TRPA1ALDH1A1MAPTPKM | |
| SCHEMBL8433401 | 0.70 | PLA2G4A (0.49) | PDPK1MAOBL3MBTL1ALDH1A1USP2 | |
| SCHEMBL28795824 | 0.70 | — | — | |
| SCHEMBL28055975 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598129-A1 | NOVEL TETRAPEPTIDE DERIVATIVE | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1994-05-25 | — | — | EP | claimed |
| US-20180222858-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | PIERRE FABRE MEDICAMENT (FR) | 2018-08-09 | — | — | US | disclosed |
| EP-2989086-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | Pierre Fabre Médicament (FR) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014174060-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | PIERRE FABRE MEDICAMENT (FR) | 2014-10-30 | — | — | WO | disclosed |
| EP-2780039-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072813-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2013-05-23 | — | — | WO | disclosed |
| EP-0731106-B1 | DOLASTATIN DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2004-11-17 | — | — | EP | disclosed |
| EP-0600744-B2 | Tumor inhibiting tetrapeptides bearing modified phenethyl amides | UNIV ARIZONA (US) | 2004-06-30 | — | — | EP | disclosed |
| CN-1146535-C | Preparing method for azide derivatives | 卫材株式会社 | 2004-04-21 | — | — | CN | disclosed |
| EP-0787009-B1 | CANCER INHIBITORY PEPTIDES | UNIV ARIZONA STATE (US) | 2004-01-21 | — | — | EP | disclosed |
| US-6004934-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1999-12-21 | — | — | US | disclosed |
| US-6004934-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0934950-A1 | Tetrapeptide derivative | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1999-08-11 | — | — | EP | disclosed |
| CN-1194264-A | Preparing method for azide derivatives | EISAI CO LTD (JP) | 1998-09-30 | — | — | CN | disclosed |
| US-5654399-A | DOLASTATIN 10 DERIVATIVE; POTENCY, LOW TOXICITY | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| US-5654399-A | DOLASTATIN 10 DERIVATIVE; POTENCY, LOW TOXICITY | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0598129-A4 | NOVEL TETRAPEPTIDE DERIVATIVE. | TEIKOKU HORMONE MFG CO LTD (JP) | 1995-10-25 | — | — | EP | disclosed |
| EP-0598129-A1 | NOVEL TETRAPEPTIDE DERIVATIVE | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1994-05-25 | — | — | EP | disclosed |
| EP-0598129-A1 | NOVEL TETRAPEPTIDE DERIVATIVE | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003054-A1 | NOVEL TETRAPEPTIDE DERIVATIVE | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1993-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222858-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | NR1H4, HCAR3, VDR | PDPK1 4580/4885TRPA1 1766/4885MAOB 3804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.