Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664500 | 0.90 | NR1H2 (0.41) | KDM4CKDM5AKDM5BHTR7NR1H2 | |
| SCHEMBL6665597 | 0.90 | ROCK2 (0.41) | KDM4CKDM5AKDM5BROCK2ROCK1 | |
| SCHEMBL6664526 | 0.89 | PARP10 (0.44) | MAOBPARP10NR4A2 | |
| SCHEMBL6664689 | 0.89 | PSEN1 (0.43) | KDM4CKDM5AKDM5BROCK2ROCK1 | |
| SCHEMBL6664479 | 0.86 | ROCK2 (0.40) | KDM5AKDM5BROCK2ROCK1PSEN1 | |
| SCHEMBL6669268 | 0.86 | ROCK2 (0.38) | KDM4CKDM5AKDM5BROCK2ROCK1 | |
| SCHEMBL6663534 | 0.85 | NNMT (0.41) | MAOBPARP10KDM5AKDM5BOPRM1 | |
| SCHEMBL6663962 | 0.85 | ROCK2 (0.46) | ROCK2ROCK1PSEN1PSEN2APH1B | |
| Niacinamide SCHEMBL6669309 | 0.80 | PSEN1 (0.41) | ROCK2HTR7PSEN1PSEN2APH1B | |
| SCHEMBL6678968 | 0.80 | NR1H2 (0.49) | KDM4CNR1H2NR1H3PARK7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014388-A1 | 6,6-FUSED HETEROARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |