Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664689 | 0.90 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6680077 | 0.87 | NR1H2 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6669268 | 0.82 | ROCK2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6664479 | 0.82 | ROCK2 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6662371 | 0.80 | MAOB (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6663962 | 0.79 | ROCK2 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6665597 | 0.79 | ROCK2 (0.41) | NR1H2NR1H3ALDH1A1ROCK2 | |
| SCHEMBL6681227 | 0.78 | PRKAG1 (0.39) | PRKAG1PRKAA2PRKAB1NR1H2NR1H3 | |
| SCHEMBL6685279 | 0.78 | NR1H2 (0.38) | NR1H2NR1H3ALDH1A1ROCK2 | |
| SCHEMBL6663534 | 0.76 | NNMT (0.41) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014388-A1 | 6,6-FUSED HETEROARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |