Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.42 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.42 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.40 |
| ▸ | CTRL | P40313 | 1/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 10/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.40 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.40 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.40 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665016 | 0.81 | REN (0.41) | CYP3A4CYP3A5CYP3A7CYP3A43REN | |
| SCHEMBL6473757 | 0.80 | CACNA1B (0.46) | CYP3A4CYP3A5CYP3A7CYP3A43REN | |
| SCHEMBL6666207 | 0.75 | CAPN1 (0.45) | RENPSMB10PSMB2PSMB5PSMB9 | |
| SCHEMBL7339983 | 0.70 | CTSS (0.59) | RENPSMB10PSMB2PSMB5PSMB9 | |
| SCHEMBL13296580 | 0.69 | MAPT (0.57) | MMP1CTSBPOLBMAPTATM | |
| SCHEMBL21981114 | 0.68 | LY96 (0.53) | POLBMAPTNPSR1TDP1 | |
| SCHEMBL6479130 | 0.68 | CTSK (0.55) | CACNA1B | |
| SCHEMBL7345558 | 0.67 | CACNA1B (0.47) | RENPSMB10PSMB2MMP1PSMB5 | |
| SCHEMBL7345553 | 0.67 | CACNA1B (0.47) | RENPSMB10PSMB2MMP1PSMB5 | |
| SCHEMBL29861037 | 0.67 | POLB (0.59) | RENMMP1POLBMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |